6E3U
Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist M1001
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005667 | cellular_component | transcription regulator complex |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0046983 | molecular_function | protein dimerization activity |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005667 | cellular_component | transcription regulator complex |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0046983 | molecular_function | protein dimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue HNJ B 401 |
| Chain | Residue |
| B | SER246 |
| B | VAL302 |
| B | TYR307 |
| B | MET309 |
| B | THR321 |
| B | ASN341 |
| B | HIS248 |
| B | MET252 |
| B | PHE254 |
| B | ALA277 |
| B | TYR278 |
| B | PHE280 |
| B | MET289 |
| B | LEU296 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Region: {"description":"Mediates the transcription activity and dimerization of the AHR:ARNT complex","evidences":[{"source":"PubMed","id":"24001774","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 70 |
| Details | Domain: {"description":"PAS 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00140","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 43 |
| Details | Domain: {"description":"PAC"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Region: {"description":"Required for heterodimer formation with ARNT","evidences":[{"source":"PubMed","id":"26245371","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
