6E3S

Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385

Summary for 6E3S

DescriptorAryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile (3 entities in total)
Functional Keywordscomplex, antagonist, transcription factor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceMus musculus (Mouse)
Total number of polymer chains2
Total molecular weight85977.69
Authors
Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F. (deposition date: 2018-07-15, release date: 2019-02-13, Last modification date: 2019-04-03)
Primary citation
Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.L.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F.
Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 15:367-376, 2019
PubMed: 30804532 (PDB entries with the same primary citation)
DOI: 10.1038/s41589-019-0234-5
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.247130 1.8% 3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6e3s
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Molmil generated image of 6e3s
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Molmil generated image of 6e3s
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