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6E3S

Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385

Functional Information from GO Data
ChainGOidnamespacecontents
A0003700molecular_functionDNA-binding transcription factor activity
A0005634cellular_componentnucleus
A0005667cellular_componenttranscription regulator complex
A0005737cellular_componentcytoplasm
A0006355biological_processregulation of DNA-templated transcription
A0046983molecular_functionprotein dimerization activity
B0003700molecular_functionDNA-binding transcription factor activity
B0005634cellular_componentnucleus
B0005667cellular_componenttranscription regulator complex
B0005737cellular_componentcytoplasm
B0006355biological_processregulation of DNA-templated transcription
B0046983molecular_functionprotein dimerization activity
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue 79A B 401
ChainResidue
BPHE244
BLEU296
BVAL302
BSER304
BMET309
BTHR321
BGLY323
BILE337
BCYS339
BASN341
BSER246
BHIS248
BMET252
BPHE254
BALA277
BPHE280
BTYR281
BHIS293

218853

PDB entries from 2024-04-24

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