6E3S
Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Aryl hydrocarbon receptor nuclear translocator | polymer | 384 | 43437.4 | 1 | UniProt (P53762) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598) In PDB | Mus musculus (Mouse) | ARNT protein,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF1-beta |
2 | B | Endothelial PAS domain-containing protein 1 | polymer | 368 | 42157.0 | 1 | UniProt (P97481) Pfam (PF00989) Pfam (PF14598) In PDB | Mus musculus (Mouse) | EPAS-1,HIF-1-alpha-like factor,mHLF,HIF-related factor,HRF,Hypoxia-inducible factor 2-alpha,HIF2-alpha |
3 | B | 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile | non-polymer | 383.3 | 1 | Chemie (79A) |
Sequence modifications
A: 82 - 464 (UniProt: P53762)
B: 3 - 362 (UniProt: P97481)
PDB | External Database | Details |
---|---|---|
Met 81 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Met 2 | - | initiating methionine |
Ala 318 | Trp 318 | engineered mutation |
Glu 363 | - | expression tag |
His 364 | - | expression tag |
His 365 | - | expression tag |
His 366 | - | expression tag |
His 367 | - | expression tag |
His 368 | - | expression tag |
His 369 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 85594.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 383.3 | |
All* | Total formula weight | 85977.7 |