5I4Z

Structure of apo OmoMYC

Summary for 5I4Z

DescriptorMyc proto-oncogene protein, GLYCEROL, CHLORIDE ION, ... (5 entities in total)
Functional Keywordsleucine zipper, transcription factor, tumor suppressor, e-box, transcription
Biological sourceHomo sapiens (Human)
Cellular locationNucleus, nucleoplasm  P01106
Total number of polymer chains2
Total molecular weight28532.93
Authors
Koelmel, W.,Jung, L.A.,Kuper, J.,Eilers, M.,Kisker, C. (deposition date: 2016-02-13, release date: 2016-10-26, Last modification date: 2017-04-19)
Primary citation
Jung, L.A.,Gebhardt, A.,Koelmel, W.,Ade, C.P.,Walz, S.,Kuper, J.,von Eyss, B.,Letschert, S.,Redel, C.,d'Artista, L.,Biankin, A.,Zender, L.,Sauer, M.,Wolf, E.,Evan, G.,Kisker, C.,Eilers, M.
OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
Oncogene, 36:1911-1924, 2017
PubMed: 27748763 (PDB entries with the same primary citation)
DOI: 10.1038/onc.2016.354
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19630 2.2% 4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02