6OD5

Human TCF4 C-terminal bHLH domain in Complex with 12-bp Oligonucleotide Containing E-box Sequence with 5-carboxylcytosines

Summary for 6OD5

• Entry DOI: 10.2210/pdb6od5/pdb
• Descriptor: Transcription factor 4, DNA (5'-D(*AP*(1CC)P*GP*CP*AP*CP*GP*TP*GP*(1CC)P*G)-3'), 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: protein-dna complex, transcription factor, bhth, e-box, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 45050.48

Authors

Horton, J.R.,Cheng, X.,Yang, J. (deposition date: 2019-03-25, release date: 2019-05-29, Last modification date: 2023-10-11)

• Primary citation: Yang, J.,Horton, J.R.,Li, J.,Huang, Y.,Zhang, X.,Blumenthal, R.M.,Cheng, X.; Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine.; Nucleic Acids Res., 47:8375-8387, 2019; PubMed: 31081034; DOI: 10.1093/nar/gkz381

Experimental method

X-RAY DIFFRACTION (2.05 Å)