6OD5
Human TCF4 C-terminal bHLH domain in Complex with 12-bp Oligonucleotide Containing E-box Sequence with 5-carboxylcytosines
Summary for 6OD5
Entry DOI | 10.2210/pdb6od5/pdb |
Descriptor | Transcription factor 4, DNA (5'-D(*AP*(1CC)P*GP*CP*AP*CP*GP*TP*GP*(1CC)P*G)-3'), 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | protein-dna complex, transcription factor, bhth, e-box, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 45050.48 |
Authors | Horton, J.R.,Cheng, X.,Yang, J. (deposition date: 2019-03-25, release date: 2019-05-29, Last modification date: 2023-10-11) |
Primary citation | Yang, J.,Horton, J.R.,Li, J.,Huang, Y.,Zhang, X.,Blumenthal, R.M.,Cheng, X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res., 47:8375-8387, 2019 Cited by PubMed: 31081034DOI: 10.1093/nar/gkz381 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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