4ZPR

Crystal Structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA

Summary for 4ZPR

Related4ZP4 4ZPH 4ZPK
DescriptorAryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 1-alpha, DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ... (4 entities in total)
Functional Keywordsarnt, hif-1a, hre, bhlh-pas, protein transport-transcription-dna complex, protein transport/transcription/dna
Biological sourceMus musculus (Mouse)
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Cellular locationNucleus P53762
Cytoplasm  Q61221
Total number of polymer chains4
Total molecular weight96229.26
Authors
Wu, D.,Potluri, N.,Lu, J.,Kim, Y.,Rastinejad, F. (deposition date: 2015-05-08, release date: 2015-08-12, Last modification date: 2017-11-22)
Primary citation
Wu, D.,Potluri, N.,Lu, J.,Kim, Y.,Rastinejad, F.
Structural integration in hypoxia-inducible factors.
Nature, 524:303-308, 2015
PubMed: 26245371 (PDB entries with the same primary citation)
DOI: 10.1038/nature14883
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.902 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.34216 0.4% 0.2% 5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171313
PDB entries from 2020-11-18