4ZPR
Crystal Structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aryl hydrocarbon receptor nuclear translocator | polymer | 384 | 43437.4 | 1 | UniProt (P53762) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598) | Mus musculus (Mouse) | ARNT protein, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF1-beta |
| 2 | B (B) | Hypoxia-inducible factor 1-alpha | polymer | 345 | 39901.6 | 1 | UniProt (Q61221) Pfam (PF00989) Pfam (PF08447) | Mus musculus (Mouse) | HIF1-alpha, ARNT-interacting protein, Hypoxia inducible factor 1, alpha subunit |
| 3 | C (C) | DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3') | polymer | 21 | 6527.2 | 1 | Mus musculus | ||
| 4 | D (D) | DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3') | polymer | 21 | 6363.1 | 1 | Mus musculus |
Sequence modifications
A: 82 - 464 (UniProt: P53762)
| PDB | External Database | Details |
|---|---|---|
| Met 81 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96229.3 | |
| All* | Total formula weight | 96229.3 |
