Crystal Structure of the Heterodimeric NPAS3-ARNT Complex with HRE DNA

Summary for 5SY7

DescriptorAryl hydrocarbon receptor nuclear translocator, Neuronal PAS domain-containing protein 3, DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ... (4 entities in total)
Functional Keywordsbhlh-pas protein, transcription factor, heterodimeric complex, transcription-dna complex, transcription/dna
Biological sourceMus musculus (Mouse)
Cellular locationNucleus P53762 Q9QZQ0
Total number of polymer chains4
Total molecular weight102553.37
Wu, D.,Su, X.,Potluri, N.,Kim, Y.,Rastinejad, F. (deposition date: 2016-08-10, release date: 2016-11-09)
Primary citation
Wu, D.,Su, X.,Potluri, N.,Kim, Y.,Rastinejad, F.
NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
Elife, 5:-, 2016
PubMed: 27782878 (PDB entries with the same primary citation)
DOI: 10.7554/eLife.18790
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.363180.2%1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution