5SY7

Crystal Structure of the Heterodimeric NPAS3-ARNT Complex with HRE DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Aryl hydrocarbon receptor nuclear translocator	polymer	384	43437.4	1	UniProt (P53762) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598) In PDB	Mus musculus (Mouse)	ARNT protein,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF1-beta
2	B	Neuronal PAS domain-containing protein 3	polymer	410	46225.7	1	UniProt (Q9QZQ0) Pfam (PF00989) Pfam (PF08447) In PDB	Mus musculus (Mouse)	Neuronal PAS3,Basic-helix-loop-helix-PAS protein MOP6,Member of PAS protein 6
3	C	DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3')	polymer	21	6527.2	1		Mus musculus
4	D	DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3')	polymer	21	6363.1	1		Mus musculus

Sequence modifications

A: 82 - 464 (UniProt: P53762)

PDB	External Database	Details
Met 81	-	initiating methionine

B: 56 - 455 (UniProt: Q9QZQ0)

PDB	External Database	Details
Met 54	-	initiating methionine
Ile 55	-	expression tag
Ser 302	Pro 302	conflict
Val 456	-	expression tag
Glu 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag
His 461	-	expression tag
His 462	-	expression tag
His 463	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	102553.4
All*	Total formula weight	102553.4

*Water molecules are not included.