3RZF
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![BU of 3rzf by Molmil](/molmil-images/mine/3rzf) | Crystal Structure of Inhibitor of kappaB kinase beta (I4122) | 分子名称: | (4-{[4-(4-chlorophenyl)pyrimidin-2-yl]amino}phenyl)[4-(2-hydroxyethyl)piperazin-1-yl]methanone, MGC80376 protein | 著者 | Xu, G, Lo, Y.C, Li, Q, Napolitano, G, Wu, X, Jiang, X, Dreano, M, Karin, M, Wu, H. | 登録日 | 2011-05-11 | 公開日 | 2011-05-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Crystal structure of inhibitor of KappaB kinase Beta. Nature, 472, 2011
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3SDJ
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![BU of 3sdj by Molmil](/molmil-images/mine/3sdj) | Structure of RNase-inactive point mutant of oligomeric kinase/RNase Ire1 | 分子名称: | N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Korennykh, A, Korostelev, A, Egea, P, Finer-Moore, J, Zhang, C, Stroud, R, Shokat, K, Walter, P. | 登録日 | 2011-06-09 | 公開日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Structural and functional basis for RNA cleavage by Ire1. Bmc Biol., 9, 2011
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3J4Q
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6NO7
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![BU of 6no7 by Molmil](/molmil-images/mine/6no7) | Crystal Structure of the full-length wild-type PKA RIa Holoenzyme | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... | 著者 | Lu, T, Wu, J, Taylor, S.S. | 登録日 | 2019-01-15 | 公開日 | 2019-07-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | 主引用文献 | Two PKA RI alpha holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP. Proc.Natl.Acad.Sci.USA, 116, 2019
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8JPC
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![BU of 8jpc by Molmil](/molmil-images/mine/8jpc) | cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2 | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8JPB
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![BU of 8jpb by Molmil](/molmil-images/mine/8jpb) | cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1 | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8H6J
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![BU of 8h6j by Molmil](/molmil-images/mine/8h6j) | Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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8H6E
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![BU of 8h6e by Molmil](/molmil-images/mine/8h6e) | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-17 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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1BLX
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![BU of 1blx by Molmil](/molmil-images/mine/1blx) | P19INK4D/CDK6 COMPLEX | 分子名称: | CALCIUM ION, CYCLIN-DEPENDENT KINASE 6, P19INK4D | 著者 | Brotherton, D.H, Dhanaraj, V, Wick, S, Brizuela, L, Domaille, P.J, Volyanik, E, Xu, X, Parisini, E, Smith, B.O, Archer, S.J, Serrano, M, Brenner, S.L, Blundell, T.L, Laue, E.D. | 登録日 | 1998-07-21 | 公開日 | 1999-06-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. Nature, 395, 1998
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6WJG
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![BU of 6wjg by Molmil](/molmil-images/mine/6wjg) | PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma | 分子名称: | DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit | 著者 | Lu, T.-W, Aoto, P.C, Weng, J.-H, Nielsen, C, Cash, J.N, Hall, J, Zhang, P, Simon, S.M, Cianfrocco, M.A, Taylor, S.S. | 登録日 | 2020-04-13 | 公開日 | 2020-12-02 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. Plos Biol., 18, 2020
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6WJF
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![BU of 6wjf by Molmil](/molmil-images/mine/6wjf) | PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma | 分子名称: | DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit | 著者 | Lu, T.-W, Aoto, P.C, Weng, J.-H, Nielsen, C, Cash, J.N, Hall, J, Zhang, P, Simon, S.M, Cianfrocco, M.A, Taylor, S.S. | 登録日 | 2020-04-13 | 公開日 | 2020-12-02 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (7.5 Å) | 主引用文献 | Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. Plos Biol., 18, 2020
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7T4V
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![BU of 7t4v by Molmil](/molmil-images/mine/7t4v) | Crystal Structure of cGMP-dependent Protein Kinase | 分子名称: | 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-methylbenzoic acid, CHLORIDE ION, cGMP-dependent protein kinase 1 | 著者 | Zebisch, M, Silvestre, L, Fischmann, T.O. | 登録日 | 2021-12-10 | 公開日 | 2023-06-14 | 最終更新日 | 2023-07-12 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Selective small molecule activation of PKG1alpha: structure and function Commun Biol, 2023
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7T4W
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![BU of 7t4w by Molmil](/molmil-images/mine/7t4w) | Crystal Structure of cGMP-dependent Protein Kinase | 分子名称: | (2R)-2-({(2S,3S)-1-[(1H-benzimidazol-2-yl)methyl]-2-phenylpiperidin-3-yl}oxy)-2-(3,5-dichlorophenyl)ethan-1-ol, CHLORIDE ION, cGMP-dependent protein kinase 1 | 著者 | Zebisch, M, Silvestre, L, Fischmann, T.O. | 登録日 | 2021-12-10 | 公開日 | 2023-06-14 | 最終更新日 | 2023-07-12 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Selective small molecule activation of PKG1alpha: structure and function Commun Biol, 2023
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7T4T
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![BU of 7t4t by Molmil](/molmil-images/mine/7t4t) | Crystal Structure of cGMP-dependent Protein Kinase | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | 著者 | Zebisch, M, Silvestre, L, Fischmann, T.O. | 登録日 | 2021-12-10 | 公開日 | 2023-06-14 | 最終更新日 | 2023-07-12 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Selective small molecule activation of PKG1alpha: structure and function Commun Biol, 2023
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7T4U
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4X6R
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![BU of 4x6r by Molmil](/molmil-images/mine/4x6r) | An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Zhang, P, Ye, F, Bastidas, A.C, Kornev, A.P, Ginsberg, M.H, Wu, J, Taylor, S.S. | 登録日 | 2014-12-09 | 公開日 | 2015-07-22 | 最終更新日 | 2020-06-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure, 23, 2015
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4X6Q
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![BU of 4x6q by Molmil](/molmil-images/mine/4x6q) | An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes | 分子名称: | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit | 著者 | Zhang, P, Ye, F, Bastidas, A.C, Kornev, A.P, Ginsberg, M.H, Taylor, S.S. | 登録日 | 2014-12-08 | 公開日 | 2015-07-22 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure, 23, 2015
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8EM8
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![BU of 8em8 by Molmil](/molmil-images/mine/8em8) | Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165 | 分子名称: | UNKNOWN ATOM OR ION, [(3R)-3-{[(4M)-4-(4-cyclopropyl-2-phenyl-1H-imidazol-1-yl)pyrimidin-2-yl]amino}pyrrolidin-1-yl](1,3-thiazol-2-yl)methanone, cGMP-dependent protein kinase, ... | 著者 | Hutchinson, A, Dong, A, Seitova, A, Bhanot, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2022-09-27 | 公開日 | 2022-11-02 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. J.Med.Chem., 67, 2024
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5FET
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![BU of 5fet by Molmil](/molmil-images/mine/5fet) | Crystal Structure of PVX_084705 in presence of Compound 2 | 分子名称: | 4-[7-[(dimethylamino)methyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-amine, cGMP-dependent protein kinase, putative | 著者 | Wernimont, A.K, Tempel, W, Walker, J.R, He, H, Seitova, A, Hills, T, Neculai, A.M, Baker, D.A, Flueck, C, Kettleborough, C.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Structural Genomics Consortium (SGC) | 登録日 | 2015-12-17 | 公開日 | 2016-01-13 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | 主引用文献 | Crystal Structure of PVX_084705 in presence of Compound 2 To be published
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7LV3
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![BU of 7lv3 by Molmil](/molmil-images/mine/7lv3) | Crystal structure of human protein kinase G (PKG) R-C complex in inhibited state | 分子名称: | 1,2-ETHANEDIOL, Isoform Beta of cGMP-dependent protein kinase 1, MANGANESE (II) ION, ... | 著者 | Sharma, R, Lying, Q, Casteel, D, Kim, C. | 登録日 | 2021-02-23 | 公開日 | 2022-08-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | An auto-inhibited state of protein kinase G and implications for selective activation. Elife, 11, 2022
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7MT8
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![BU of 7mt8 by Molmil](/molmil-images/mine/7mt8) | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin | 分子名称: | RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... | 著者 | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2021-05-13 | 公開日 | 2021-07-07 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | 主引用文献 | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
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7MTB
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![BU of 7mtb by Molmil](/molmil-images/mine/7mtb) | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6 | 分子名称: | Fab6 heavy chain, Fab6 light chain, RETINAL, ... | 著者 | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2021-05-13 | 公開日 | 2021-07-07 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
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7MTA
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![BU of 7mta by Molmil](/molmil-images/mine/7mta) | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1 | 分子名称: | Fab1 Heavy chain, Fab1 Light chain, RETINAL, ... | 著者 | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2021-05-13 | 公開日 | 2021-07-07 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
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7MT9
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![BU of 7mt9 by Molmil](/molmil-images/mine/7mt9) | Rhodopsin kinase (GRK1) in complex with rhodopsin | 分子名称: | RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... | 著者 | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2021-05-13 | 公開日 | 2021-07-07 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
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8R08
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![BU of 8r08 by Molmil](/molmil-images/mine/8r08) | Cryo-EM structure of the cross-exon pre-B+AMPPNP complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, NHP2-like protein 1, N-terminally processed, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-31 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
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