6NO7
Crystal Structure of the full-length wild-type PKA RIa Holoenzyme
Summary for 6NO7
Entry DOI | 10.2210/pdb6no7/pdb |
Related | 2QCS |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type I-alpha regulatory subunit, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | pka, ria holoenzyme, atp-dependent, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 335931.47 |
Authors | Lu, T.,Wu, J.,Taylor, S.S. (deposition date: 2019-01-15, release date: 2019-07-24, Last modification date: 2023-10-11) |
Primary citation | Lu, T.W.,Wu, J.,Aoto, P.C.,Weng, J.H.,Ahuja, L.G.,Sun, N.,Cheng, C.Y.,Zhang, P.,Taylor, S.S. Two PKA RI alpha holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP. Proc.Natl.Acad.Sci.USA, 116:16347-16356, 2019 Cited by PubMed: 31363049DOI: 10.1073/pnas.1906036116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.55 Å) |
Structure validation
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