Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6NO7

Crystal Structure of the full-length wild-type PKA RIa Holoenzyme

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0001669	cellular_component	acrosomal vesicle
A	0001707	biological_process	mesoderm formation
A	0001843	biological_process	neural tube closure
A	0002027	biological_process	regulation of heart rate
A	0003091	biological_process	renal water homeostasis
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004679	molecular_function	AMP-activated protein kinase activity
A	0004691	molecular_function	cAMP-dependent protein kinase activity
A	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005930	cellular_component	axoneme
A	0005952	cellular_component	cAMP-dependent protein kinase complex
A	0006397	biological_process	mRNA processing
A	0006468	biological_process	protein phosphorylation
A	0006611	biological_process	protein export from nucleus
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0010737	biological_process	protein kinase A signaling
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0016241	biological_process	regulation of macroautophagy
A	0016607	cellular_component	nuclear speck
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0019901	molecular_function	protein kinase binding
A	0019904	molecular_function	protein domain specific binding
A	0030145	molecular_function	manganese ion binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0031514	cellular_component	motile cilium
A	0031594	cellular_component	neuromuscular junction
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032024	biological_process	positive regulation of insulin secretion
A	0032703	biological_process	negative regulation of interleukin-2 production
A	0034237	molecular_function	protein kinase A regulatory subunit binding
A	0034380	biological_process	high-density lipoprotein particle assembly
A	0034605	biological_process	cellular response to heat
A	0034704	cellular_component	calcium channel complex
A	0035694	biological_process	mitochondrial protein catabolic process
A	0036126	cellular_component	sperm flagellum
A	0043197	cellular_component	dendritic spine
A	0044853	cellular_component	plasma membrane raft
A	0045667	biological_process	regulation of osteoblast differentiation
A	0045722	biological_process	positive regulation of gluconeogenesis
A	0045879	biological_process	negative regulation of smoothened signaling pathway
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0048240	biological_process	sperm capacitation
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0050850	biological_process	positive regulation of calcium-mediated signaling
A	0051726	biological_process	regulation of cell cycle
A	0055117	biological_process	regulation of cardiac muscle contraction
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0070062	cellular_component	extracellular exosome
A	0070417	biological_process	cellular response to cold
A	0070613	biological_process	regulation of protein processing
A	0071333	biological_process	cellular response to glucose stimulus
A	0071374	biological_process	cellular response to parathyroid hormone stimulus
A	0071377	biological_process	cellular response to glucagon stimulus
A	0071872	biological_process	cellular response to epinephrine stimulus
A	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
A	0097546	cellular_component	ciliary base
A	0098978	cellular_component	glutamatergic synapse
A	0099103	molecular_function	channel activator activity
A	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
A	0106310	molecular_function	protein serine kinase activity
A	1903779	biological_process	regulation of cardiac conduction
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
A	1990044	biological_process	protein localization to lipid droplet
A	2000810	biological_process	regulation of bicellular tight junction assembly
B	0001707	biological_process	mesoderm formation
B	0001772	cellular_component	immunological synapse
B	0001932	biological_process	regulation of protein phosphorylation
B	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005771	cellular_component	multivesicular body
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005930	cellular_component	axoneme
B	0005952	cellular_component	cAMP-dependent protein kinase complex
B	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
B	0007507	biological_process	heart development
B	0008603	molecular_function	cAMP-dependent protein kinase regulator activity
B	0010629	biological_process	negative regulation of gene expression
B	0019904	molecular_function	protein domain specific binding
B	0030552	molecular_function	cAMP binding
B	0031588	cellular_component	nucleotide-activated protein kinase complex
B	0031594	cellular_component	neuromuscular junction
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032024	biological_process	positive regulation of insulin secretion
B	0032991	cellular_component	protein-containing complex
B	0034236	molecular_function	protein kinase A catalytic subunit binding
B	0042802	molecular_function	identical protein binding
B	0044853	cellular_component	plasma membrane raft
B	0045202	cellular_component	synapse
B	0045214	biological_process	sarcomere organization
B	0046007	biological_process	negative regulation of activated T cell proliferation
B	0060038	biological_process	cardiac muscle cell proliferation
B	0071377	biological_process	cellular response to glucagon stimulus
B	0097224	cellular_component	sperm connecting piece
B	0098978	cellular_component	glutamatergic synapse
C	0000287	molecular_function	magnesium ion binding
C	0001669	cellular_component	acrosomal vesicle
C	0001707	biological_process	mesoderm formation
C	0001843	biological_process	neural tube closure
C	0002027	biological_process	regulation of heart rate
C	0003091	biological_process	renal water homeostasis
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004679	molecular_function	AMP-activated protein kinase activity
C	0004691	molecular_function	cAMP-dependent protein kinase activity
C	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005930	cellular_component	axoneme
C	0005952	cellular_component	cAMP-dependent protein kinase complex
C	0006397	biological_process	mRNA processing
C	0006468	biological_process	protein phosphorylation
C	0006611	biological_process	protein export from nucleus
C	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
C	0010737	biological_process	protein kinase A signaling
C	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C	0016241	biological_process	regulation of macroautophagy
C	0016607	cellular_component	nuclear speck
C	0018105	biological_process	peptidyl-serine phosphorylation
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0019901	molecular_function	protein kinase binding
C	0019904	molecular_function	protein domain specific binding
C	0030145	molecular_function	manganese ion binding
C	0031410	cellular_component	cytoplasmic vesicle
C	0031514	cellular_component	motile cilium
C	0031594	cellular_component	neuromuscular junction
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032024	biological_process	positive regulation of insulin secretion
C	0032703	biological_process	negative regulation of interleukin-2 production
C	0034237	molecular_function	protein kinase A regulatory subunit binding
C	0034380	biological_process	high-density lipoprotein particle assembly
C	0034605	biological_process	cellular response to heat
C	0034704	cellular_component	calcium channel complex
C	0035694	biological_process	mitochondrial protein catabolic process
C	0036126	cellular_component	sperm flagellum
C	0043197	cellular_component	dendritic spine
C	0044853	cellular_component	plasma membrane raft
C	0045667	biological_process	regulation of osteoblast differentiation
C	0045722	biological_process	positive regulation of gluconeogenesis
C	0045879	biological_process	negative regulation of smoothened signaling pathway
C	0046827	biological_process	positive regulation of protein export from nucleus
C	0048240	biological_process	sperm capacitation
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050804	biological_process	modulation of chemical synaptic transmission
C	0050850	biological_process	positive regulation of calcium-mediated signaling
C	0051726	biological_process	regulation of cell cycle
C	0055117	biological_process	regulation of cardiac muscle contraction
C	0061136	biological_process	regulation of proteasomal protein catabolic process
C	0070062	cellular_component	extracellular exosome
C	0070417	biological_process	cellular response to cold
C	0070613	biological_process	regulation of protein processing
C	0071333	biological_process	cellular response to glucose stimulus
C	0071374	biological_process	cellular response to parathyroid hormone stimulus
C	0071377	biological_process	cellular response to glucagon stimulus
C	0071872	biological_process	cellular response to epinephrine stimulus
C	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
C	0097546	cellular_component	ciliary base
C	0098978	cellular_component	glutamatergic synapse
C	0099103	molecular_function	channel activator activity
C	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
C	0106310	molecular_function	protein serine kinase activity
C	1903779	biological_process	regulation of cardiac conduction
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
C	1990044	biological_process	protein localization to lipid droplet
C	2000810	biological_process	regulation of bicellular tight junction assembly
D	0001707	biological_process	mesoderm formation
D	0001772	cellular_component	immunological synapse
D	0001932	biological_process	regulation of protein phosphorylation
D	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005771	cellular_component	multivesicular body
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005930	cellular_component	axoneme
D	0005952	cellular_component	cAMP-dependent protein kinase complex
D	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
D	0007507	biological_process	heart development
D	0008603	molecular_function	cAMP-dependent protein kinase regulator activity
D	0010629	biological_process	negative regulation of gene expression
D	0019904	molecular_function	protein domain specific binding
D	0030552	molecular_function	cAMP binding
D	0031588	cellular_component	nucleotide-activated protein kinase complex
D	0031594	cellular_component	neuromuscular junction
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032024	biological_process	positive regulation of insulin secretion
D	0032991	cellular_component	protein-containing complex
D	0034236	molecular_function	protein kinase A catalytic subunit binding
D	0042802	molecular_function	identical protein binding
D	0044853	cellular_component	plasma membrane raft
D	0045202	cellular_component	synapse
D	0045214	biological_process	sarcomere organization
D	0046007	biological_process	negative regulation of activated T cell proliferation
D	0060038	biological_process	cardiac muscle cell proliferation
D	0071377	biological_process	cellular response to glucagon stimulus
D	0097224	cellular_component	sperm connecting piece
D	0098978	cellular_component	glutamatergic synapse
E	0000287	molecular_function	magnesium ion binding
E	0001669	cellular_component	acrosomal vesicle
E	0001707	biological_process	mesoderm formation
E	0001843	biological_process	neural tube closure
E	0002027	biological_process	regulation of heart rate
E	0003091	biological_process	renal water homeostasis
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004679	molecular_function	AMP-activated protein kinase activity
E	0004691	molecular_function	cAMP-dependent protein kinase activity
E	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005930	cellular_component	axoneme
E	0005952	cellular_component	cAMP-dependent protein kinase complex
E	0006397	biological_process	mRNA processing
E	0006468	biological_process	protein phosphorylation
E	0006611	biological_process	protein export from nucleus
E	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
E	0010737	biological_process	protein kinase A signaling
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0016241	biological_process	regulation of macroautophagy
E	0016607	cellular_component	nuclear speck
E	0018105	biological_process	peptidyl-serine phosphorylation
E	0019221	biological_process	cytokine-mediated signaling pathway
E	0019901	molecular_function	protein kinase binding
E	0019904	molecular_function	protein domain specific binding
E	0030145	molecular_function	manganese ion binding
E	0031410	cellular_component	cytoplasmic vesicle
E	0031514	cellular_component	motile cilium
E	0031594	cellular_component	neuromuscular junction
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032024	biological_process	positive regulation of insulin secretion
E	0032703	biological_process	negative regulation of interleukin-2 production
E	0034237	molecular_function	protein kinase A regulatory subunit binding
E	0034380	biological_process	high-density lipoprotein particle assembly
E	0034605	biological_process	cellular response to heat
E	0034704	cellular_component	calcium channel complex
E	0035694	biological_process	mitochondrial protein catabolic process
E	0036126	cellular_component	sperm flagellum
E	0043197	cellular_component	dendritic spine
E	0044853	cellular_component	plasma membrane raft
E	0045667	biological_process	regulation of osteoblast differentiation
E	0045722	biological_process	positive regulation of gluconeogenesis
E	0045879	biological_process	negative regulation of smoothened signaling pathway
E	0046827	biological_process	positive regulation of protein export from nucleus
E	0048240	biological_process	sperm capacitation
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050804	biological_process	modulation of chemical synaptic transmission
E	0050850	biological_process	positive regulation of calcium-mediated signaling
E	0051726	biological_process	regulation of cell cycle
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0061136	biological_process	regulation of proteasomal protein catabolic process
E	0070062	cellular_component	extracellular exosome
E	0070417	biological_process	cellular response to cold
E	0070613	biological_process	regulation of protein processing
E	0071333	biological_process	cellular response to glucose stimulus
E	0071374	biological_process	cellular response to parathyroid hormone stimulus
E	0071377	biological_process	cellular response to glucagon stimulus
E	0071872	biological_process	cellular response to epinephrine stimulus
E	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
E	0097546	cellular_component	ciliary base
E	0098978	cellular_component	glutamatergic synapse
E	0099103	molecular_function	channel activator activity
E	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
E	0106310	molecular_function	protein serine kinase activity
E	1903779	biological_process	regulation of cardiac conduction
E	1904262	biological_process	negative regulation of TORC1 signaling
E	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
E	1990044	biological_process	protein localization to lipid droplet
E	2000810	biological_process	regulation of bicellular tight junction assembly
F	0001707	biological_process	mesoderm formation
F	0001772	cellular_component	immunological synapse
F	0001932	biological_process	regulation of protein phosphorylation
F	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005771	cellular_component	multivesicular body
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005930	cellular_component	axoneme
F	0005952	cellular_component	cAMP-dependent protein kinase complex
F	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
F	0007507	biological_process	heart development
F	0008603	molecular_function	cAMP-dependent protein kinase regulator activity
F	0010629	biological_process	negative regulation of gene expression
F	0019904	molecular_function	protein domain specific binding
F	0030552	molecular_function	cAMP binding
F	0031588	cellular_component	nucleotide-activated protein kinase complex
F	0031594	cellular_component	neuromuscular junction
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032024	biological_process	positive regulation of insulin secretion
F	0032991	cellular_component	protein-containing complex
F	0034236	molecular_function	protein kinase A catalytic subunit binding
F	0042802	molecular_function	identical protein binding
F	0044853	cellular_component	plasma membrane raft
F	0045202	cellular_component	synapse
F	0045214	biological_process	sarcomere organization
F	0046007	biological_process	negative regulation of activated T cell proliferation
F	0060038	biological_process	cardiac muscle cell proliferation
F	0071377	biological_process	cellular response to glucagon stimulus
F	0097224	cellular_component	sperm connecting piece
F	0098978	cellular_component	glutamatergic synapse
G	0000287	molecular_function	magnesium ion binding
G	0001669	cellular_component	acrosomal vesicle
G	0001707	biological_process	mesoderm formation
G	0001843	biological_process	neural tube closure
G	0002027	biological_process	regulation of heart rate
G	0003091	biological_process	renal water homeostasis
G	0004672	molecular_function	protein kinase activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0004679	molecular_function	AMP-activated protein kinase activity
G	0004691	molecular_function	cAMP-dependent protein kinase activity
G	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005930	cellular_component	axoneme
G	0005952	cellular_component	cAMP-dependent protein kinase complex
G	0006397	biological_process	mRNA processing
G	0006468	biological_process	protein phosphorylation
G	0006611	biological_process	protein export from nucleus
G	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
G	0010737	biological_process	protein kinase A signaling
G	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G	0016241	biological_process	regulation of macroautophagy
G	0016607	cellular_component	nuclear speck
G	0018105	biological_process	peptidyl-serine phosphorylation
G	0019221	biological_process	cytokine-mediated signaling pathway
G	0019901	molecular_function	protein kinase binding
G	0019904	molecular_function	protein domain specific binding
G	0030145	molecular_function	manganese ion binding
G	0031410	cellular_component	cytoplasmic vesicle
G	0031514	cellular_component	motile cilium
G	0031594	cellular_component	neuromuscular junction
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032024	biological_process	positive regulation of insulin secretion
G	0032703	biological_process	negative regulation of interleukin-2 production
G	0034237	molecular_function	protein kinase A regulatory subunit binding
G	0034380	biological_process	high-density lipoprotein particle assembly
G	0034605	biological_process	cellular response to heat
G	0034704	cellular_component	calcium channel complex
G	0035694	biological_process	mitochondrial protein catabolic process
G	0036126	cellular_component	sperm flagellum
G	0043197	cellular_component	dendritic spine
G	0044853	cellular_component	plasma membrane raft
G	0045667	biological_process	regulation of osteoblast differentiation
G	0045722	biological_process	positive regulation of gluconeogenesis
G	0045879	biological_process	negative regulation of smoothened signaling pathway
G	0046827	biological_process	positive regulation of protein export from nucleus
G	0048240	biological_process	sperm capacitation
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0050804	biological_process	modulation of chemical synaptic transmission
G	0050850	biological_process	positive regulation of calcium-mediated signaling
G	0051726	biological_process	regulation of cell cycle
G	0055117	biological_process	regulation of cardiac muscle contraction
G	0061136	biological_process	regulation of proteasomal protein catabolic process
G	0070062	cellular_component	extracellular exosome
G	0070417	biological_process	cellular response to cold
G	0070613	biological_process	regulation of protein processing
G	0071333	biological_process	cellular response to glucose stimulus
G	0071374	biological_process	cellular response to parathyroid hormone stimulus
G	0071377	biological_process	cellular response to glucagon stimulus
G	0071872	biological_process	cellular response to epinephrine stimulus
G	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
G	0097546	cellular_component	ciliary base
G	0098978	cellular_component	glutamatergic synapse
G	0099103	molecular_function	channel activator activity
G	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
G	0106310	molecular_function	protein serine kinase activity
G	1903779	biological_process	regulation of cardiac conduction
G	1904262	biological_process	negative regulation of TORC1 signaling
G	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
G	1990044	biological_process	protein localization to lipid droplet
G	2000810	biological_process	regulation of bicellular tight junction assembly
H	0001707	biological_process	mesoderm formation
H	0001772	cellular_component	immunological synapse
H	0001932	biological_process	regulation of protein phosphorylation
H	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005771	cellular_component	multivesicular body
H	0005813	cellular_component	centrosome
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005930	cellular_component	axoneme
H	0005952	cellular_component	cAMP-dependent protein kinase complex
H	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
H	0007507	biological_process	heart development
H	0008603	molecular_function	cAMP-dependent protein kinase regulator activity
H	0010629	biological_process	negative regulation of gene expression
H	0019904	molecular_function	protein domain specific binding
H	0030552	molecular_function	cAMP binding
H	0031588	cellular_component	nucleotide-activated protein kinase complex
H	0031594	cellular_component	neuromuscular junction
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032024	biological_process	positive regulation of insulin secretion
H	0032991	cellular_component	protein-containing complex
H	0034236	molecular_function	protein kinase A catalytic subunit binding
H	0042802	molecular_function	identical protein binding
H	0044853	cellular_component	plasma membrane raft
H	0045202	cellular_component	synapse
H	0045214	biological_process	sarcomere organization
H	0046007	biological_process	negative regulation of activated T cell proliferation
H	0060038	biological_process	cardiac muscle cell proliferation
H	0071377	biological_process	cellular response to glucagon stimulus
H	0097224	cellular_component	sperm connecting piece
H	0098978	cellular_component	glutamatergic synapse

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue MG E 401

Chain	Residue
E	LYS168
E	ATP403

site_id	AC2
Number of Residues	3
Details	binding site for residue MG E 402

Chain	Residue
E	ASP166
E	ASP184
E	ATP403

site_id	AC3
Number of Residues	17
Details	binding site for residue ATP E 403

Chain	Residue
E	PHE54
E	VAL57
E	LYS72
E	GLU127
E	ASP166
E	LYS168
E	LEU173
E	THR183
E	ASP184
E	PHE327
E	MG401
E	MG402
F	ALA97
E	GLY50
E	THR51
E	GLY52
E	SER53

site_id	AC4
Number of Residues	3
Details	binding site for residue MG G 401

Chain	Residue
G	GLU170
G	ASN171
G	ATP403

site_id	AC5
Number of Residues	5
Details	binding site for residue MG G 402

Chain	Residue
G	ASP166
G	LYS168
G	ASN171
G	ASP184
G	ATP403

site_id	AC6
Number of Residues	17
Details	binding site for residue ATP G 403

Chain	Residue
G	GLY52
G	VAL57
G	ALA70
G	LYS72
G	MET120
G	GLU121
G	TYR122
G	VAL123
G	GLU127
G	ASP166
G	LYS168
G	ASN171
G	LEU173
G	THR183
G	ASP184
G	MG401
G	MG402

Functional Information from PROSITE/UniProt

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElALiygtp......RAAtVkA

Chain	Residue	Details
B	PHE198-ALA215
B	PHE322-ALA339

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. VIqQGDeGDnFYVIdqG

Chain	Residue	Details
B	VAL162-GLY178
B	ILE280-GLY296

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhketgnh..........YAMK

Chain	Residue	Details
A	LEU49-LYS72

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI

Chain	Residue	Details
A	LEU162-ILE174

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
B	GLU324
B	ARG333
D	LEU135
D	GLU200
D	ARG209
D	ILE253
D	GLU324
D	ARG333
F	LEU135
F	GLU200
F	ARG209
F	ILE253
F	GLU324
F	ARG333
H	LEU135
H	GLU200
H	ARG209
H	ILE253
H	GLU324
H	ARG333
B	LEU135
B	GLU200
B	ARG209
B	ILE253

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0000250\|UniProtKB:P10644

Chain	Residue	Details
B	MET0
D	MET0
F	MET0
H	MET0

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylalanine; in cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed => ECO:0000269\|PubMed:6487597

Chain	Residue	Details
E	LYS168
G	LYS72
G	GLU121
G	LYS168
B	ALA1
D	ALA1
F	ALA1
H	ALA1
C	GLU121
C	LYS168
E	LYS72
E	GLU121

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P09456

Chain	Residue	Details
B	SER2
B	SER256
D	SER2
D	SER256
F	SER2
F	SER256
H	SER2
H	SER256

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P10644

Chain	Residue	Details
F	SER75
F	SER81
H	SER75
H	SER81
B	SER75
B	SER81
D	SER75
D	SER81

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q9DBC7

Chain	Residue	Details
B	SER99
D	SER99
F	SER99
H	SER99

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P05132

Chain	Residue	Details
A	SEP139
C	SEP139
E	SEP139
G	SEP139

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:12372837

Chain	Residue	Details
A	THR195
C	THR195
E	THR195
G	THR195

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269\|PubMed:12372837, ECO:0000269\|PubMed:16765046, ECO:0000269\|PubMed:20137943, ECO:0000269\|PubMed:20481595, ECO:0000269\|PubMed:20732331, ECO:0000269\|PubMed:21774789, ECO:0000269\|Ref.43

Chain	Residue	Details
A	TPO197
C	TPO197
E	TPO197
G	TPO197

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P05132

Chain	Residue	Details
A	TYR330
C	TYR330
E	TYR330
G	TYR330

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:16765046, ECO:0000269\|PubMed:20137943, ECO:0000269\|PubMed:20481595, ECO:0000269\|PubMed:20732331, ECO:0000269\|PubMed:21774789, ECO:0000269\|Ref.43, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SEP338
C	SEP338
E	SEP338
G	SEP338

site_id	SWS_FT_FI12
Number of Residues	4
Details	LIPID: N-myristoyl glycine => ECO:0000269\|PubMed:25255805, ECO:0000269\|PubMed:25807930

Chain	Residue	Details
A	GLY1
C	GLY1
E	GLY1
G	GLY1

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)