2QCS

A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state

Summary for 2QCS

Entry DOI	10.2210/pdb2qcs/pdb
Related	1APM 1NE4 1NE6 1RGS
Descriptor	cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase type I-alpha regulatory subunit, MANGANESE (II) ION, ... (9 entities in total)
Functional Keywords	cyclic adenosine monophosphate, camp-dependent protein kinase, pka holoenzyme, cyclic nucleotide binding domain, protein-protein interaction, conformational change, protein binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mus musculus (house mouse) More
Cellular location	Cytoplasm . Isoform 2: Cell projection, cilium, flagellum : P05132 Cell membrane : P00514
Total number of polymer chains	2
Total formula weight	75151.43
Authors	Kim, C.,Cheng, C.Y.,Saldanha, A.S.,Taylor, S.S. (deposition date: 2007-06-19, release date: 2007-11-06, Last modification date: 2023-08-30)
Primary citation	Kim, C.,Cheng, C.Y.,Saldanha, S.A.,Taylor, S.S. PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell(Cambridge,Mass.), 130:1032-1043, 2007 Cited by PubMed: 17889648 DOI: 10.1016/j.cell.2007.07.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation