6WJG

PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma

Summary for 6WJG

Entry DOI	10.2210/pdb6wjg/pdb
EMDB information	21693
Descriptor	DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit (2 entities in total)
Functional Keywords	fibrolamellar hepatoceullar carcinoma, pka, kinase, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	187031.67
Authors	Lu, T.-W.,Aoto, P.C.,Weng, J.-H.,Nielsen, C.,Cash, J.N.,Hall, J.,Zhang, P.,Simon, S.M.,Cianfrocco, M.A.,Taylor, S.S. (deposition date: 2020-04-13, release date: 2020-12-02, Last modification date: 2024-03-06)
Primary citation	Lu, T.W.,Aoto, P.C.,Weng, J.H.,Nielsen, C.,Cash, J.N.,Hall, J.,Zhang, P.,Simon, S.M.,Cianfrocco, M.A.,Taylor, S.S. Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. Plos Biol., 18:e3001018-e3001018, 2020 Cited by PubMed: 33370777 DOI: 10.1371/journal.pbio.3001018 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (6.2 Å)

Structure validation