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6WJG

PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001669cellular_componentacrosomal vesicle
A0001707biological_processmesoderm formation
A0001843biological_processneural tube closure
A0002027biological_processregulation of heart rate
A0003091biological_processrenal water homeostasis
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004679molecular_functionAMP-activated protein kinase activity
A0004691molecular_functioncAMP-dependent protein kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0005952cellular_componentcAMP-dependent protein kinase complex
A0006397biological_processmRNA processing
A0006468biological_processprotein phosphorylation
A0006611biological_processprotein export from nucleus
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0010737biological_processprotein kinase A signaling
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0016241biological_processregulation of macroautophagy
A0016607cellular_componentnuclear speck
A0018105biological_processpeptidyl-serine phosphorylation
A0019221biological_processcytokine-mediated signaling pathway
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0030145molecular_functionmanganese ion binding
A0031410cellular_componentcytoplasmic vesicle
A0031514cellular_componentmotile cilium
A0031594cellular_componentneuromuscular junction
A0031625molecular_functionubiquitin protein ligase binding
A0032024biological_processpositive regulation of insulin secretion
A0032703biological_processnegative regulation of interleukin-2 production
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034380biological_processhigh-density lipoprotein particle assembly
A0034605biological_processcellular response to heat
A0034704cellular_componentcalcium channel complex
A0035694biological_processmitochondrial protein catabolic process
A0036126cellular_componentsperm flagellum
A0043197cellular_componentdendritic spine
A0044853cellular_componentplasma membrane raft
A0045667biological_processregulation of osteoblast differentiation
A0045722biological_processpositive regulation of gluconeogenesis
A0045879biological_processnegative regulation of smoothened signaling pathway
A0046827biological_processpositive regulation of protein export from nucleus
A0048240biological_processsperm capacitation
A0048471cellular_componentperinuclear region of cytoplasm
A0050804biological_processmodulation of chemical synaptic transmission
A0050850biological_processpositive regulation of calcium-mediated signaling
A0051726biological_processregulation of cell cycle
A0055117biological_processregulation of cardiac muscle contraction
A0061136biological_processregulation of proteasomal protein catabolic process
A0070062cellular_componentextracellular exosome
A0070417biological_processcellular response to cold
A0070613biological_processregulation of protein processing
A0071333biological_processcellular response to glucose stimulus
A0071374biological_processcellular response to parathyroid hormone stimulus
A0071377biological_processcellular response to glucagon stimulus
A0071872biological_processcellular response to epinephrine stimulus
A0086064biological_processcell communication by electrical coupling involved in cardiac conduction
A0097546cellular_componentciliary base
A0098978cellular_componentglutamatergic synapse
A0099103molecular_functionchannel activator activity
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0106310molecular_functionprotein serine kinase activity
A1903779biological_processregulation of cardiac conduction
A1904262biological_processnegative regulation of TORC1 signaling
A1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
A1990044biological_processprotein localization to lipid droplet
A2000810biological_processregulation of bicellular tight junction assembly
B0000287molecular_functionmagnesium ion binding
B0001669cellular_componentacrosomal vesicle
B0001707biological_processmesoderm formation
B0001843biological_processneural tube closure
B0002027biological_processregulation of heart rate
B0003091biological_processrenal water homeostasis
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004679molecular_functionAMP-activated protein kinase activity
B0004691molecular_functioncAMP-dependent protein kinase activity
B0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005930cellular_componentaxoneme
B0005952cellular_componentcAMP-dependent protein kinase complex
B0006397biological_processmRNA processing
B0006468biological_processprotein phosphorylation
B0006611biological_processprotein export from nucleus
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0010737biological_processprotein kinase A signaling
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0016241biological_processregulation of macroautophagy
B0016607cellular_componentnuclear speck
B0018105biological_processpeptidyl-serine phosphorylation
B0019221biological_processcytokine-mediated signaling pathway
B0019901molecular_functionprotein kinase binding
B0019904molecular_functionprotein domain specific binding
B0030145molecular_functionmanganese ion binding
B0031410cellular_componentcytoplasmic vesicle
B0031514cellular_componentmotile cilium
B0031594cellular_componentneuromuscular junction
B0031625molecular_functionubiquitin protein ligase binding
B0032024biological_processpositive regulation of insulin secretion
B0032703biological_processnegative regulation of interleukin-2 production
B0034237molecular_functionprotein kinase A regulatory subunit binding
B0034380biological_processhigh-density lipoprotein particle assembly
B0034605biological_processcellular response to heat
B0034704cellular_componentcalcium channel complex
B0035694biological_processmitochondrial protein catabolic process
B0036126cellular_componentsperm flagellum
B0043197cellular_componentdendritic spine
B0044853cellular_componentplasma membrane raft
B0045667biological_processregulation of osteoblast differentiation
B0045722biological_processpositive regulation of gluconeogenesis
B0045879biological_processnegative regulation of smoothened signaling pathway
B0046827biological_processpositive regulation of protein export from nucleus
B0048240biological_processsperm capacitation
B0048471cellular_componentperinuclear region of cytoplasm
B0050804biological_processmodulation of chemical synaptic transmission
B0050850biological_processpositive regulation of calcium-mediated signaling
B0051726biological_processregulation of cell cycle
B0055117biological_processregulation of cardiac muscle contraction
B0061136biological_processregulation of proteasomal protein catabolic process
B0070062cellular_componentextracellular exosome
B0070417biological_processcellular response to cold
B0070613biological_processregulation of protein processing
B0071333biological_processcellular response to glucose stimulus
B0071374biological_processcellular response to parathyroid hormone stimulus
B0071377biological_processcellular response to glucagon stimulus
B0071872biological_processcellular response to epinephrine stimulus
B0086064biological_processcell communication by electrical coupling involved in cardiac conduction
B0097546cellular_componentciliary base
B0098978cellular_componentglutamatergic synapse
B0099103molecular_functionchannel activator activity
B0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B0106310molecular_functionprotein serine kinase activity
B1903779biological_processregulation of cardiac conduction
B1904262biological_processnegative regulation of TORC1 signaling
B1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
B1990044biological_processprotein localization to lipid droplet
B2000810biological_processregulation of bicellular tight junction assembly
C0001932biological_processregulation of protein phosphorylation
C0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005952cellular_componentcAMP-dependent protein kinase complex
C0006631biological_processfatty acid metabolic process
C0007612biological_processlearning
C0008603molecular_functioncAMP-dependent protein kinase regulator activity
C0019901molecular_functionprotein kinase binding
C0019904molecular_functionprotein domain specific binding
C0030425cellular_componentdendrite
C0030552molecular_functioncAMP binding
C0031625molecular_functionubiquitin protein ligase binding
C0034236molecular_functionprotein kinase A catalytic subunit binding
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0043198cellular_componentdendritic shaft
C0048471cellular_componentperinuclear region of cytoplasm
C0050804biological_processmodulation of chemical synaptic transmission
C0097332biological_processresponse to antipsychotic drug
C0097546cellular_componentciliary base
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
D0001932biological_processregulation of protein phosphorylation
D0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005952cellular_componentcAMP-dependent protein kinase complex
D0006631biological_processfatty acid metabolic process
D0007612biological_processlearning
D0008603molecular_functioncAMP-dependent protein kinase regulator activity
D0019901molecular_functionprotein kinase binding
D0019904molecular_functionprotein domain specific binding
D0030425cellular_componentdendrite
D0030552molecular_functioncAMP binding
D0031625molecular_functionubiquitin protein ligase binding
D0034236molecular_functionprotein kinase A catalytic subunit binding
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0043198cellular_componentdendritic shaft
D0048471cellular_componentperinuclear region of cytoplasm
D0050804biological_processmodulation of chemical synaptic transmission
D0097332biological_processresponse to antipsychotic drug
D0097546cellular_componentciliary base
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhketgnh..........YAMK
ChainResidueDetails
ALEU104-LYS127

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
ChainResidueDetails
ALEU217-ILE229

site_idPS00636
Number of Residues20
DetailsDNAJ_1 Nt-dnaJ domain signature. FKeIAeaYDvLsDprkREIF
ChainResidueDetails
APHE44-PHE63

site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. VIdQGDdGDnFYVIdrG
ChainResidueDetails
CVAL179-GLY195
CILE301-GLY317

site_idPS00889
Number of Residues18
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElALmyntp......RAAtItA
ChainResidueDetails
CPHE219-ALA236
CPHE348-ALA365

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING:
ChainResidueDetails
CLEU152
DPHE274
DGLU350
DARG359
CGLU221
CARG230
CPHE274
CGLU350
CARG359
DLEU152
DGLU221
DARG230

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P31323
ChainResidueDetails
CTHR69
DTHR69

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
CSER83
CSER85
DSER83
DSER85
BPHE184
BGLN231

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16641100, ECO:0007744|PubMed:22673903
ChainResidueDetails
CSER112
DSER112

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976
ChainResidueDetails
AARG111
BARG111

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P05132
ChainResidueDetails
AALA202
BALA202

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:12372837
ChainResidueDetails
AGLU258
BGLU258

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:12372837, ECO:0000269|PubMed:16765046, ECO:0000269|PubMed:20137943, ECO:0000269|PubMed:20481595, ECO:0000269|PubMed:20732331, ECO:0000269|PubMed:21774789, ECO:0000269|Ref.43
ChainResidueDetails
ALEU260
BLEU260

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P05132
ChainResidueDetails
ASER393
BSER393

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:16765046, ECO:0000269|PubMed:20137943, ECO:0000269|PubMed:20481595, ECO:0000269|PubMed:20732331, ECO:0000269|PubMed:21774789, ECO:0000269|Ref.43, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569
ChainResidueDetails
AGLU401
BGLU401

220113

PDB entries from 2024-05-22

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