6WJF
PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma
Summary for 6WJF
Entry DOI | 10.2210/pdb6wjf/pdb |
EMDB information | 21692 |
Descriptor | DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit (2 entities in total) |
Functional Keywords | fibrolamellar hepatoceullar carcinoma, pka, camp, kinase, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 187031.67 |
Authors | Lu, T.-W.,Aoto, P.C.,Weng, J.-H.,Nielsen, C.,Cash, J.N.,Hall, J.,Zhang, P.,Simon, S.M.,Cianfrocco, M.A.,Taylor, S.S. (deposition date: 2020-04-13, release date: 2020-12-02, Last modification date: 2024-03-06) |
Primary citation | Lu, T.W.,Aoto, P.C.,Weng, J.H.,Nielsen, C.,Cash, J.N.,Hall, J.,Zhang, P.,Simon, S.M.,Cianfrocco, M.A.,Taylor, S.S. Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. Plos Biol., 18:e3001018-e3001018, 2020 Cited by PubMed: 33370777DOI: 10.1371/journal.pbio.3001018 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (7.5 Å) |
Structure validation
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