8EM8

Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165

Summary for 8EM8

• Entry DOI: 10.2210/pdb8em8/pdb
• Descriptor: cGMP-dependent protein kinase, unidentified peptide fragment, [(3R)-3-{[(4M)-4-(4-cyclopropyl-2-phenyl-1H-imidazol-1-yl)pyrimidin-2-yl]amino}pyrrolidin-1-yl](1,3-thiazol-2-yl)methanone, ... (5 entities in total)
• Functional Keywords: sgc, cgmp-kinase, inhibitor, structural genomics, structural genomics consortium, transferase
• Biological source: Plasmodium falciparum (isolate 3D7); More
• Total number of polymer chains: 2
• Total formula weight: 98630.55

Authors

Hutchinson, A.,Dong, A.,Seitova, A.,Bhanot, P.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2022-09-27, release date: 2022-11-02, Last modification date: 2023-10-18)

• Primary citation: Hutchinson, A.,Dong, A.,Seitova, A.,Bhanot, P.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC); Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.54 Å)