PDB: 941 件ウェブページステータス検索Chemie searchBIRD

---

8FLQ	Human PTH1R in complex with PTH(1-34) and Gs 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. 登録日 2022-12-22 公開日 2023-04-26 最終更新日 2023-06-14 実験手法 ELECTRON MICROSCOPY (2.55 Å) 主引用文献 Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
8FLS	Human PTH1R in complex with Abaloparatide and Gs 分子名称: Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. 登録日 2022-12-22 公開日 2023-04-26 最終更新日 2023-06-14 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
8G2Y	Cryo-EM structure of ADGRF1 coupled to miniGs/q 分子名称: Adhesion G-protein-coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Jones, D, Rawson, S, Blacklow, S. 登録日 2023-02-06 公開日 2023-05-10 実験手法 ELECTRON MICROSCOPY (3.44 Å) 主引用文献 Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling. Nat Commun, 14, 2023
8FX5	Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline 分子名称: Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Vuckovic, Z, Mobbs, J.I, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. 登録日 2023-01-23 公開日 2023-09-13 実験手法 ELECTRON MICROSCOPY (2.45 Å) 主引用文献 Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR. Nat Commun, 14, 2023
8G05	Cryo-EM structure of an orphan GPCR-Gi protein signaling complex 分子名称: 6-(octylamino)pyrimidine-2,4(3H,5H)-dione, CHOLESTEROL, G-protein coupled receptor 84, ... 著者 Zhang, X, Wang, Y.J, Li, X, Liu, G.B, Gong, W.M, Zhang, C. 登録日 2023-01-31 公開日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Pro-phagocytic function and structural basis of GPR84 signaling. Nat Commun, 14, 2023
8FY8	5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex 分子名称: 2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethan-1-amine, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. 登録日 2023-01-25 公開日 2024-05-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.79 Å) 主引用文献 Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
8FYE	4-F, 5-MeO-PyrT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex 分子名称: 4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. 登録日 2023-01-26 公開日 2024-05-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
8FYL	Vilazodone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex 分子名称: 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. 登録日 2023-01-26 公開日 2024-05-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
8FYT	LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex 分子名称: (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. 登録日 2023-01-26 公開日 2024-05-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.64 Å) 主引用文献 Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
8FYX	Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex 分子名称: Buspirone, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. 登録日 2023-01-26 公開日 2024-05-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.62 Å) 主引用文献 Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
8GY7	Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein 分子名称: CALCIUM ION, Corticotropin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Luo, P, Feng, W.B, Ma, S.S, Dai, A.T, Yuan, Q.N, Wu, K, Yang, D.H, Wang, M.W, Xu, H.E, Jiang, Y. 登録日 2022-09-21 公開日 2023-01-11 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1. Cell Res., 33, 2023
8G59	Cryo-EM structure of the TUG891 bound GPR120-Giq complex 分子名称: 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. 登録日 2023-02-12 公開日 2023-03-08 最終更新日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.64 Å) 主引用文献 Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
8GUS	Cryo-EM structure of HU-CB2-G protein complex 分子名称: Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H. 登録日 2022-09-13 公開日 2023-05-10 実験手法 ELECTRON MICROSCOPY (2.97 Å) 主引用文献 Structural basis of selective cannabinoid CB 2 receptor activation. Nat Commun, 14, 2023
8GHV	Cannabinoid Receptor 1-G Protein Complex 分子名称: (5Z,8Z,11Z,13S,14Z)-N-[(2R)-1-hydroxypropan-2-yl]-13-methylicosa-5,8,11,14-tetraenamide, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Krishna Kumar, K, Robertson, M.J, Skiniotis, G, Kobilka, B.K. 登録日 2023-03-12 公開日 2023-05-24 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural basis for activation of CB1 by an endocannabinoid analog. Nat Commun, 14, 2023
8GUQ	Cryo-EM structure of CB2-G protein complex 分子名称: Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H. 登録日 2022-09-13 公開日 2023-05-10 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.08 Å) 主引用文献 Structural basis of selective cannabinoid CB 2 receptor activation. Nat Commun, 14, 2023
8GUT	Cryo-EM structure of LEI-CB2-Gi complex 分子名称: 1-[[4-[5-fluoranyl-6-[(oxan-4-ylamino)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Liu, Z.J, Hua, T, Li, X.T, Chang, H, Wu, L.J. 登録日 2022-09-13 公開日 2023-05-10 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Structural basis of selective cannabinoid CB 2 receptor activation. Nat Commun, 14, 2023
8GUR	Cryo-EM structure of CP-CB2-G protein complex 分子名称: 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H. 登録日 2022-09-13 公開日 2023-05-10 実験手法 ELECTRON MICROSCOPY (2.84 Å) 主引用文献 Structural basis of selective cannabinoid CB 2 receptor activation. Nat Commun, 14, 2023
8GW8	the human PTH1 receptor bound to an intracellular biased agonist 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Kobayashi, K, Kusakizako, T, Okamoto, H.H, Nureki, O. 登録日 2022-09-16 公開日 2023-06-14 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Class B1 GPCR activation by an intracellular agonist. Nature, 618, 2023
8G94	Structure of CD69-bound S1PR1 coupled to heterotrimeric Gi 分子名称: Early activation antigen CD69, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Chen, H, Li, X. 登録日 2023-02-21 公開日 2023-04-19 最終更新日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Transmembrane protein CD69 acts as an S1PR1 agonist. Elife, 12, 2023
8FMZ	Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, MiniGq, ... 著者 Krumm, B.E, Diberto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. 登録日 2022-12-26 公開日 2023-03-29 最終更新日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.59 Å) 主引用文献 Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
8FN1	CryoEM structure of Go-coupled NTSR1 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... 著者 Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. 登録日 2022-12-26 公開日 2023-03-29 最終更新日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
8FU6	GCGR-Gs complex in the presence of RAMP2 分子名称: Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Krishna Kumar, K, O'Brien, E.S, Wang, H, Montabana, E, Kobilka, B.K. 登録日 2023-01-16 公開日 2023-04-12 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Negative allosteric modulation of the glucagon receptor by RAMP2. Cell, 186, 2023
8FEG	CryoEM structure of Kappa Opioid Receptor bound to a semi-peptide and Gi1 分子名称: ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Fay, J.F, Che, T. 登録日 2022-12-06 公開日 2023-12-06 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (2.54 Å) 主引用文献 Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor. Nat Commun, 14, 2023
8GCM	Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein 分子名称: (5S)-5-[(3R)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-one, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Huang, S.M, Xiong, M.Y, Liu, L, Mu, J, Sheng, C, Sun, J. 登録日 2023-03-02 公開日 2024-01-03 最終更新日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
8GCP	Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein 分子名称: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Huang, S.M, Xiong, M.Y, Liu, L, Mu, J, Sheng, C, Sun, J. 登録日 2023-03-02 公開日 2024-01-03 最終更新日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023

<12131415161718192021222324252627>