8FU6

GCGR-Gs complex in the presence of RAMP2

Summary for 8FU6

Entry DOI	10.2210/pdb8fu6/pdb
EMDB information	29453
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	g-protein coupled receptor, ramp, g-protein, gs, nb35, gpcr, glucagon receptor, glucagon, peptide agonist, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	166540.70
Authors	Krishna Kumar, K.,O'Brien, E.S.,Wang, H.,Montabana, E.,Kobilka, B.K. (deposition date: 2023-01-16, release date: 2023-04-12)
Primary citation	Krishna Kumar, K.,O'Brien, E.S.,Habrian, C.H.,Latorraca, N.R.,Wang, H.,Tuneew, I.,Montabana, E.,Marqusee, S.,Hilger, D.,Isacoff, E.Y.,Mathiesen, J.M.,Kobilka, B.K. Negative allosteric modulation of the glucagon receptor by RAMP2. Cell, 186:1465-1477.e18, 2023 Cited by PubMed: 37001505 DOI: 10.1016/j.cell.2023.02.028 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation