8G2Y

Cryo-EM structure of ADGRF1 coupled to miniGs/q

Summary for 8G2Y

• Entry DOI: 10.2210/pdb8g2y/pdb
• EMDB information: 29684
• Descriptor: MiniG alpha s/q chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, agonist, g protein, signaling, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 161147.44

Authors

Jones, D.,Rawson, S.,Blacklow, S. (deposition date: 2023-02-06, release date: 2023-05-10)

• Primary citation: Jones, D.T.D.,Dates, A.N.,Rawson, S.D.,Burruss, M.M.,Lipper, C.H.,Blacklow, S.C.; Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling.; Nat Commun, 14:2490-2490, 2023; PubMed: 37120430; DOI: 10.1038/s41467-023-38083-7

Experimental method

ELECTRON MICROSCOPY (3.44 Å)