8FYL

Vilazodone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex

Summary for 8FYL

Entry DOI	10.2210/pdb8fyl/pdb
EMDB information	29585
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
Functional Keywords	gpcr signaling complex, serotonin receptor, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	151985.68
Authors	Warren, A.L.,Zilberg, G.,Capper, M.J.,Wacker, D. (deposition date: 2023-01-26, release date: 2024-05-15, Last modification date: 2024-06-19)
Primary citation	Warren, A.L.,Lankri, D.,Cunningham, M.J.,Serrano, I.C.,Parise, L.F.,Kruegel, A.C.,Duggan, P.,Zilberg, G.,Capper, M.J.,Havel, V.,Russo, S.J.,Sames, D.,Wacker, D. Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630:237-246, 2024 Cited by PubMed: 38720072 DOI: 10.1038/s41586-024-07403-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.94 Å)

Structure validation