8FN1

CryoEM structure of Go-coupled NTSR1

Summary for 8FN1

• Entry DOI: 10.2210/pdb8fn1/pdb
• EMDB information: 29303
• Descriptor: Neurotensin/neuromedin N, Neurotensin receptor type 1, Guanine nucleotide-binding protein G(o) subunit alpha, ... (6 entities in total)
• Functional Keywords: gpcr, neurotensin receptor, allosterism, sbi-553, membrane protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 148060.42

Authors

Krumm, B.E.,DiBerto, J.F.,Olsen, R.H.J.,Kang, H.,Slocum, S.T.,Zhang, S.,Strachan, R.T.,Fay, J.F.,Roth, B.L. (deposition date: 2022-12-26, release date: 2023-03-29, Last modification date: 2023-04-19)

• Primary citation: Krumm, B.E.,DiBerto, J.F.,Olsen, R.H.J.,Kang, H.J.,Slocum, S.T.,Zhang, S.,Strachan, R.T.,Huang, X.P.,Slosky, L.M.,Pinkerton, A.B.,Barak, L.S.,Caron, M.G.,Kenakin, T.,Fay, J.F.,Roth, B.L.; Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.; Biochemistry, 62:1233-1248, 2023; PubMed: 36917754; DOI: 10.1021/acs.biochem.3c00029

Experimental method

ELECTRON MICROSCOPY (2.88 Å)