8G94

Structure of CD69-bound S1PR1 coupled to heterotrimeric Gi

Summary for 8G94

• Entry DOI: 10.2210/pdb8g94/pdb
• EMDB information: 29861
• Descriptor: Sphingosine 1-phosphate receptor 1, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: cd69, s1pr1, sphingosine-1-phosphate, lymphocyte egress, gpcr, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 201728.62

Authors

Chen, H.,Li, X. (deposition date: 2023-02-21, release date: 2023-04-19, Last modification date: 2023-04-26)

• Primary citation: Chen, H.,Qin, Y.,Chou, M.,Cyster, J.G.,Li, X.; Transmembrane protein CD69 acts as an S1PR1 agonist.; Elife, 12:-, 2023; PubMed: 37039481; DOI: 10.7554/eLife.88204

Experimental method

ELECTRON MICROSCOPY (3.15 Å)