8FMZ

Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator

Summary for 8FMZ

Entry DOI	10.2210/pdb8fmz/pdb
EMDB information	29301
Descriptor	MiniGq, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	gpcr, neurotensin receptor, allosterism, sbi-553, membrane protein
Biological source	Escherichia coli More
Total number of polymer chains	6
Total formula weight	150284.66
Authors	Krumm, B.E.,Diberto, J.F.,Olsen, R.H.J.,Kang, H.,Slocum, S.T.,Zhang, S.,Strachan, R.T.,Fay, J.F.,Roth, B.L. (deposition date: 2022-12-26, release date: 2023-03-29, Last modification date: 2023-04-19)
Primary citation	Krumm, B.E.,DiBerto, J.F.,Olsen, R.H.J.,Kang, H.J.,Slocum, S.T.,Zhang, S.,Strachan, R.T.,Huang, X.P.,Slosky, L.M.,Pinkerton, A.B.,Barak, L.S.,Caron, M.G.,Kenakin, T.,Fay, J.F.,Roth, B.L. Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62:1233-1248, 2023 Cited by PubMed: 36917754 DOI: 10.1021/acs.biochem.3c00029 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.59 Å)

Structure validation