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8FMZ

Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator

Functional Information from GO Data
ChainGOidnamespacecontents
A0004930molecular_functionG protein-coupled receptor activity
A0007186biological_processG protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
A0016492molecular_functionG protein-coupled neurotensin receptor activity
B0003924molecular_functionGTPase activity
B0005525molecular_functionGTP binding
B0007186biological_processG protein-coupled receptor signaling pathway
B0019001molecular_functionguanyl nucleotide binding
B0031683molecular_functionG-protein beta/gamma-subunit complex binding
C0001750cellular_componentphotoreceptor outer segment
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
C0007265biological_processRas protein signal transduction
C0008283biological_processcell population proliferation
C0016020cellular_componentmembrane
C0030159molecular_functionsignaling receptor complex adaptor activity
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0050909biological_processsensory perception of taste
C0051020molecular_functionGTPase binding
C0060041biological_processretina development in camera-type eye
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
C0097381cellular_componentphotoreceptor disc membrane
C1903561cellular_componentextracellular vesicle
D0005515molecular_functionprotein binding
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0031681molecular_functionG-protein beta-subunit binding
D0045202cellular_componentsynapse
D0048144biological_processfibroblast proliferation
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ATAlNVASLSVERYLaI
ChainResidueDetails
AALA155-ILE171

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
CLEU70-SER84
CILE157-ILE171
CLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by MME => ECO:0000250|UniProtKB:P30990
ChainResidueDetails
FPRO10

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Cleavage; by ACE and MME => ECO:0000250|UniProtKB:P30990
ChainResidueDetails
FTYR11
AGLU166-ARG185
AALA261-LEU308

site_idSWS_FT_FI3
Number of Residues19
DetailsTRANSMEM: Helical; Name=2
ChainResidueDetails
ATYR104-VAL123

site_idSWS_FT_FI4
Number of Residues64
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:24453215
ChainResidueDetails
AGLU124-ARG143
ATHR207-LYS235
APHE331-HIS348

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3
ChainResidueDetails
AGLY144-VAL165

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4
ChainResidueDetails
ATHR186-PHE206

site_idSWS_FT_FI7
Number of Residues24
DetailsTRANSMEM: Helical; Name=5
ChainResidueDetails
AVAL236-ILE260

site_idSWS_FT_FI8
Number of Residues21
DetailsTRANSMEM: Helical; Name=6
ChainResidueDetails
AVAL309-MET330

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7
ChainResidueDetails
ATYR349-TYR369

site_idSWS_FT_FI10
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P30989
ChainResidueDetails
ACYS386
ACYS388

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PDB entries from 2025-06-11

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