8FMZ
Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | MiniGq | polymer | 246 | 28084.8 | 1 | Escherichia coli | ||
| 2 | B (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (E) | scFv16 | polymer | 267 | 28668.9 | 1 | Lama glama | ||
| 5 | E (A) | Neurotensin receptor type 1 | polymer | 405 | 45432.7 | 1 | UniProt (P20789) Pfam (PF00001) | Rattus norvegicus (Norway rat) | NT-R-1,NTR1,High-affinity levocabastine-insensitive neurotensin receptor,NTRH |
| 6 | F (F) | Neurotensin/neuromedin N | polymer | 6 | 819.0 | 1 | UniProt (P20068) | Rattus norvegicus |
Sequence modifications
C: 2 - 340 (UniProt: P62873)
A: 43 - 420 (UniProt: P20789)
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | expression tag |
| His 17 | - | expression tag |
| His 18 | - | expression tag |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| His 21 | - | expression tag |
| His 22 | - | expression tag |
| His 23 | - | expression tag |
| His 24 | - | expression tag |
| His 25 | - | expression tag |
| His 26 | - | expression tag |
| Ser 27 | - | expression tag |
| Asp 28 | - | expression tag |
| Leu 29 | - | expression tag |
| Glu 30 | - | expression tag |
| Val 31 | - | expression tag |
| Leu 32 | - | expression tag |
| Phe 33 | - | expression tag |
| Gln 34 | - | expression tag |
| Gly 35 | - | expression tag |
| Pro 36 | - | expression tag |
| Leu 37 | - | expression tag |
| Gly 38 | - | expression tag |
| Ser 39 | - | expression tag |
| Gly 40 | - | expression tag |
| Ala 41 | - | expression tag |
| Pro 42 | - | expression tag |
| Leu 86 | Ala 86 | engineered mutation |
| Ala 215 | Gly 215 | engineered mutation |
| Ala 360 | Val 360 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 150284.7 | |
| All* | Total formula weight | 150284.7 |
