8U4C
| Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation. | 分子名称: | Insulin receptor, Insulin-like growth factor II | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2023-09-10 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8U4E
| Cryo-EM structure of long form insulin receptor (IR-B) with three IGF2 bound, asymmetric conformation. | 分子名称: | Insulin receptor, Insulin-like growth factor II | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2023-09-10 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8VJC
| Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation. | 分子名称: | Insulin-like growth factor II, Isoform Short of Insulin receptor | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2024-01-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8VJB
| Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation. | 分子名称: | Insulin-like growth factor II, Isoform Short of Insulin receptor | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2024-01-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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6UM2
| Structure of M-6-P/IGFII Receptor and IGFII complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, Insulin-like growth factor II | 著者 | Wang, R, Qi, X, Li, X. | 登録日 | 2019-10-08 | 公開日 | 2020-02-26 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.32 Å) | 主引用文献 | Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments Sci Adv, 6, 2020
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7MD5
| Insulin receptor ectodomain dimer complexed with two IRPA-9 partial agonists | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gomez-Llorente, Y, Zhou, H, Scapin, G. | 登録日 | 2021-04-03 | 公開日 | 2022-02-23 | 最終更新日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13, 2022
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7MD4
| Insulin receptor ectodomain dimer complexed with two IRPA-3 partial agonists | 分子名称: | Insulin B chain, Insulin chain A, Isoform Short of Insulin receptor, ... | 著者 | Gomez-Llorente, Y, Zhou, H, Scapin, G. | 登録日 | 2021-04-03 | 公開日 | 2022-02-23 | 最終更新日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13, 2022
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7U6E
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8EZ0
| Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation | 分子名称: | Insulin, Insulin receptor | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | 登録日 | 2022-10-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EYX
| Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Asymmetric conformation 1 | 分子名称: | Insulin, Insulin receptor | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | 登録日 | 2022-10-29 | 公開日 | 2022-11-09 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EYY
| Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S, denoted as IR-3CS) Asymmetric conformation 2 | 分子名称: | Insulin, Insulin receptor | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | 登録日 | 2022-10-29 | 公開日 | 2022-11-09 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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7BW7
| Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin. | 分子名称: | Insulin fusion, Insulin receptor | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | 登録日 | 2020-04-13 | 公開日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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7BW8
| Cryo-EM Structure for the Insulin Binding Region in the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin | 分子名称: | Insulin fusion, Insulin receptor | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | 登録日 | 2020-04-14 | 公開日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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7BWA
| Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 2 Insulin | 分子名称: | Insulin fusion, Insulin receptor | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | 登録日 | 2020-04-14 | 公開日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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7PG2
| Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin, conf 1 | 分子名称: | Insulin, Isoform Short of Insulin receptor | 著者 | Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. | 登録日 | 2021-08-12 | 公開日 | 2022-02-02 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (6.7 Å) | 主引用文献 | Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
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7PG0
| Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin with visible ddm micelle, conf 1 | 分子名称: | Insulin, Isoform Short of Insulin receptor | 著者 | Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. | 登録日 | 2021-08-12 | 公開日 | 2022-02-02 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | 主引用文献 | Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
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7PG4
| Low resolution Cryo-EM structure of the full-length insulin receptor bound to 2 insulin, conf 3 | 分子名称: | Insulin, Isoform Short of Insulin receptor | 著者 | Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. | 登録日 | 2021-08-12 | 公開日 | 2022-02-02 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (9.1 Å) | 主引用文献 | Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
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7PG3
| Low resolution Cryo-EM structure of the full-length insulin receptor bound to 3 insulin, conf 2 | 分子名称: | Insulin, Isoform Short of Insulin receptor | 著者 | Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. | 登録日 | 2021-08-12 | 公開日 | 2022-02-02 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | 主引用文献 | Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
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7QID
| tentative model of the human insulin receptor ectodomain bound by three insulin | 分子名称: | Insulin, Insulin receptor, Isoform Short of Insulin receptor | 著者 | Gutman, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U. | 登録日 | 2021-12-14 | 公開日 | 2022-02-02 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain J Cell Biol, 219, 2020
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6SOF
| human insulin receptor ectodomain bound by 4 insulin | 分子名称: | Insulin, Insulin receptor | 著者 | Gutmann, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U. | 登録日 | 2019-08-29 | 公開日 | 2019-11-13 | 最終更新日 | 2020-05-27 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain. J.Cell Biol., 219, 2020
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6CE9
| Insulin Receptor ectodomain in complex with two insulin molecules | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | 登録日 | 2018-02-11 | 公開日 | 2018-03-14 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
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6CEB
| Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | 登録日 | 2018-02-11 | 公開日 | 2018-03-14 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
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6CE7
| Insulin Receptor ectodomain in complex with one insulin molecule | 分子名称: | Insulin A chain, Insulin B chain, Insulin receptor, ... | 著者 | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | 登録日 | 2018-02-11 | 公開日 | 2018-03-14 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | 主引用文献 | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
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6HN5
| Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... | 著者 | Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C. | 登録日 | 2018-09-14 | 公開日 | 2018-11-21 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The signalling conformation of the insulin receptor ectodomain. Nat Commun, 9, 2018
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6PXV
| Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region. | 分子名称: | Insulin, Insulin receptor | 著者 | Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. | 登録日 | 2019-07-27 | 公開日 | 2019-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
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