7MD5

Insulin receptor ectodomain dimer complexed with two IRPA-9 partial agonists

Summary for 7MD5

Entry DOI	10.2210/pdb7md5/pdb
EMDB information	23767
Descriptor	Isoform Short of Insulin receptor, Isoform Short of Insulin receptor alpha, Insulin chain A, ... (9 entities in total)
Functional Keywords	insulin receptor, peptide binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	248400.58
Authors	Gomez-Llorente, Y.,Zhou, H.,Scapin, G. (deposition date: 2021-04-03, release date: 2022-02-23, Last modification date: 2022-03-02)
Primary citation	Wu, M.,Carballo-Jane, E.,Zhou, H.,Zafian, P.,Dai, G.,Liu, M.,Lao, J.,Kelly, T.,Shao, D.,Gorski, J.,Pissarnitski, D.,Kekec, A.,Chen, Y.,Previs, S.F.,Scapin, G.,Llorente, Y.G.,Hollingsworth, S.A.,Yan, L.,Feng, D.,Huo, P.,Walford, G.,Erion, M.D.,Kelley, D.E.,Lin, S.,Mu, J. Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13:942-942, 2022 Cited by PubMed: 35177603 DOI: 10.1038/s41467-022-28561-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5.2 Å)

Structure validation