7MD5
Insulin receptor ectodomain dimer complexed with two IRPA-9 partial agonists
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Isoform Short of Insulin receptor | polymer | 927 | 106143.4 | 2 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) In PDB | Homo sapiens (Human) | IR |
2 | M, N | Isoform Short of Insulin receptor alpha | polymer | 30 | 3459.8 | 2 | UniProt (P06213) In PDB | Homo sapiens (Human) | IR |
3 | S, O, Q, U | Insulin chain A | polymer | 21 | 2383.7 | 4 | UniProt (P01308) In PDB | Homo sapiens (Human) | |
4 | T, P, R, V | Insulin B chain | polymer | 30 | 3434.0 | 4 | UniProt (P01308) Pfam (PF00049) In PDB | Homo sapiens (Human) | |
5 | X, D, Y, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 4 | In PDB GlyTouCan (G21290RB) | |||
6 | C, G | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
7 | E, I | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
8 | F, J | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
9 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
A, B: 1 - 917 (UniProt: P06213)
M, N: 694 - 720 (UniProt: P06213)
PDB | External Database | Details |
---|---|---|
His 918 | - | expression tag |
His 919 | - | expression tag |
His 920 | - | expression tag |
His 921 | - | expression tag |
His 922 | - | expression tag |
His 923 | - | expression tag |
His 924 | - | expression tag |
His 925 | - | expression tag |
His 926 | - | expression tag |
His 927 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ala 691 | - | expression tag |
Ala 692 | - | expression tag |
Ala 693 | - | expression tag |
Ser 717 | Arg 744 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 242477.0 | |
Branched | Number of molecules | 10 |
Total formula weight | 5038.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 884.8 | |
All* | Total formula weight | 248400.6 |