7MD5
Insulin receptor ectodomain dimer complexed with two IRPA-9 partial agonists
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isoform Short of Insulin receptor | polymer | 927 | 106143.4 | 2 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) | Homo sapiens (Human) | IR |
| 2 | C, D (M, N) | Isoform Short of Insulin receptor alpha | polymer | 30 | 3459.8 | 2 | UniProt (P06213) | Homo sapiens (Human) | IR |
| 3 | E, G, I, K (S, O, Q, U) | Insulin chain A | polymer | 21 | 2383.7 | 4 | UniProt (P01308) | Homo sapiens (Human) | |
| 4 | F, H, J, L (T, P, R, V) | Insulin B chain | polymer | 30 | 3434.0 | 4 | UniProt (P01308) Pfam (PF00049) | Homo sapiens (Human) | |
| 5 | M, O, R, T (X, D, Y, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 4 | In PDB GlyTouCan (G21290RB) | |||
| 6 | N, S (C, G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 7 | P, U (E, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 8 | Q, V (F, J) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 9 | W, X, Y, Z (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
A, B: 1 - 917 (UniProt: P06213)
M, N: 694 - 720 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| His 918 | - | expression tag |
| His 919 | - | expression tag |
| His 920 | - | expression tag |
| His 921 | - | expression tag |
| His 922 | - | expression tag |
| His 923 | - | expression tag |
| His 924 | - | expression tag |
| His 925 | - | expression tag |
| His 926 | - | expression tag |
| His 927 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 691 | - | expression tag |
| Ala 692 | - | expression tag |
| Ala 693 | - | expression tag |
| Ser 717 | Arg 744 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 242477.0 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 5038.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 884.8 | |
| All* | Total formula weight | 248400.6 |
