6PXV
Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region.
Summary for 6PXV
Entry DOI | 10.2210/pdb6pxv/pdb |
EMDB information | 20522 20523 |
Descriptor | Insulin receptor, Insulin (2 entities in total) |
Functional Keywords | insulin receptor, insulin, signaling protein-hormone complex, signaling protein/hormone |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 341348.74 |
Authors | Uchikawa, E.,Choi, E.,Shang, G.J.,Yu, H.T.,Bai, X.C. (deposition date: 2019-07-27, release date: 2019-09-04) |
Primary citation | Uchikawa, E.,Choi, E.,Shang, G.,Yu, H.,Bai, X.C. Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8:-, 2019 Cited by PubMed: 31436533DOI: 10.7554/eLife.48630 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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