6PXV

Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Insulin receptor	polymer	1354	153913.3	2	UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) Pfam (PF07714) In PDB	Homo sapiens (Human)	IR
2	D, E, F, G	Insulin	polymer	74	8380.5	4	UniProt (A6XGL2) Pfam (PF00049) In PDB	Homo sapiens (Human)

Sequence modifications

A, C: 1 - 1343 (UniProt: P06213)

PDB	External Database	Details
Phe 960	Tyr 987	conflict
Thr 962	Ser 989	conflict
Asn 1120	Asp 1147	conflict
Ala 1333	Arg 1360	conflict
Ala 1334	Ile 1361	conflict
Ala 1335	Leu 1362	conflict
Ala 1337	Leu 1364	conflict
Leu 1344	-	expression tag
Glu 1345	-	expression tag
Ser 1346	-	expression tag
Ser 1347	-	expression tag
Gly 1348	-	expression tag
Leu 1349	-	expression tag
Glu 1350	-	expression tag
Val 1351	-	expression tag
Leu 1352	-	expression tag
Phe 1353	-	expression tag
Gln 1354	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	341348.7
All*	Total formula weight	341348.7

*Water molecules are not included.