7SL4
 
 | |
7SL1
 | |
8AVD
 | | Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement) | | 分子名称: | Leptin, Leptin receptor, NICKEL (II) ION | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (4.42 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
|
|
8AVO
 | | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model). | | 分子名称: | Leptin, Leptin receptor | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (6.84 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
|
|
8AVF
 | | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (closed 3:3 model) | | 分子名称: | Leptin, Leptin receptor | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (6.45 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
|
|
8AVC
 | | Mouse leptin:LEP-R complex cryoEM structure (3:3 model) | | 分子名称: | Leptin, Leptin receptor, NICKEL (II) ION | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
|
|
8AVE
 | | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model) | | 分子名称: | Leptin, Leptin receptor | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (5.62 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
|
|
8AVB
 | | Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model). | | 分子名称: | Leptin, Leptin receptor | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (4.43 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
|
|
8B7Q
 | | Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-09-30 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (4.02 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
|
|
8BXR
 | |
8CLS
 | |
8K53
 | |
8ODZ
 | | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1). | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | | 著者 | Felix, J, Bloch, Y, Savvides, S.N. | | 登録日 | 2023-03-10 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
|
|
8OE4
 | | Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | | 著者 | Bloch, Y, Felix, J, Savvides, S.N. | | 登録日 | 2023-03-10 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
|
|
8OE0
 | | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2). | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | | 著者 | Felix, J, Bloch, Y, Savvides, S.N. | | 登録日 | 2023-03-10 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
|
|
7YQ3
 | | human insulin receptor bound with A43 DNA aptamer and insulin | | 分子名称: | IR-A43 aptamer, Insulin A chain, Insulin, ... | | 著者 | Kim, J, Yunn, N, Ryu, S, Cho, Y. | | 登録日 | 2022-08-05 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.
Nat Commun, 13, 2022
|
|
7YQ4
 | | human insulin receptor bound with A62 DNA aptamer and insulin - locally refined | | 分子名称: | IR-A62 aptamer, Insulin A chain, Insulin, ... | | 著者 | Kim, J, Yunn, N, Ryu, S, Cho, Y. | | 登録日 | 2022-08-05 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | | 主引用文献 | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.
Nat Commun, 13, 2022
|
|
7YQ6
 | | human insulin receptor bound with A62 DNA aptamer | | 分子名称: | IR-A62 aptamer, Isoform Short of Insulin receptor | | 著者 | Kim, J, Yunn, N, Ryu, S, Cho, Y. | | 登録日 | 2022-08-05 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | | 主引用文献 | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.
Nat Commun, 13, 2022
|
|
7YQ5
 | | human insulin receptor bound with A62 DNA aptamer and insulin | | 分子名称: | IR-A62 aptamer, Insulin A chain, Insulin, ... | | 著者 | Kim, J, Yunn, N, Ryu, S, Cho, Y. | | 登録日 | 2022-08-05 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | | 主引用文献 | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.
Nat Commun, 13, 2022
|
|
8K3J
 | | Structure of human CNTN2 immunoglobulin domains 1-6 homo-dimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin-2, ... | | 著者 | Zhang, Z.Z. | | 登録日 | 2023-07-16 | | 公開日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of human CNTN2 immunoglobulin domains 1-6 homo-dimer
To Be Published
|
|
8PB1
 | | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | | 著者 | Felix, J, Bloch, Y, Savvides, S.N. | | 登録日 | 2023-06-08 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
|
|
7Z0L
 | | IL-27 signalling complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... | | 著者 | Jin, Y, Gardner, S, Bubeck, D. | | 登録日 | 2022-02-23 | | 公開日 | 2022-07-27 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural insights into the assembly and activation of the IL-27 signaling complex.
Embo Rep., 23, 2022
|
|
1ZLG
 | | Solution structure of the extracellular matrix protein anosmin-1 | | 分子名称: | Anosmin 1 | | 著者 | Hu, Y, Sun, Z, Eaton, J.T, Bouloux, P.M, Perkins, S.J. | | 登録日 | 2005-05-06 | | 公開日 | 2006-05-09 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION SCATTERING | | 主引用文献 | Extended and Flexible Domain Solution Structure of the Extracellular Matrix Protein Anosmin-1 by X-ray Scattering, Analytical Ultracentrifugation and Constrained Modelling.
J.Mol.Biol., 350, 2005
|
|
2AEW
 | |
4UI2
 | | Crystal structure of the ternary RGMB-BMP2-NEO1 complex | | 分子名称: | ACETATE ION, BONE MORPHOGENETIC PROTEIN 2, BMP2, ... | | 著者 | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | | 登録日 | 2015-03-27 | | 公開日 | 2015-05-06 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
|
|
