8AVE
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model)
Summary for 8AVE
| Entry DOI | 10.2210/pdb8ave/pdb |
| Related | 7z3q 7z3r |
| EMDB information | 15680 |
| Descriptor | Leptin, Leptin receptor (2 entities in total) |
| Functional Keywords | leptin, lep-r, obesity, metabolism, energy balance, cytokine |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 234854.25 |
| Authors | Verstraete, K.,Savvides, S.N.,Verschueren, K.G.,Tsirigotaki, A. (deposition date: 2022-08-26, release date: 2023-04-05, Last modification date: 2023-04-26) |
| Primary citation | Tsirigotaki, A.,Dansercoer, A.,Verschueren, K.H.G.,Markovic, I.,Pollmann, C.,Hafer, M.,Felix, J.,Birck, C.,Van Putte, W.,Catteeuw, D.,Tavernier, J.,Fernando Bazan, J.,Piehler, J.,Savvides, S.N.,Verstraete, K. Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30:551-563, 2023 Cited by PubMed: 36959263DOI: 10.1038/s41594-023-00941-9 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (5.62 Å) |
Structure validation
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