8AVE

Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Leptin	polymer	171	18605.1	2	UniProt (P41159) Pfam (PF02024) In PDB	Homo sapiens (human)	Obese protein,Obesity factor
2	B, D	Leptin receptor	polymer	868	98822.1	2	UniProt (P48357) Pfam (PF18589) Pfam (PF06328) In PDB	Homo sapiens (human)	LEP-R,HuB219,OB receptor,OB-R

Sequence modifications

A, C: 22 - 167 (UniProt: P41159)

PDB	External Database	Details
Ala -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
Pro 4	-	expression tag
Gly 5	-	expression tag
Gly 6	-	expression tag
Pro 7	-	expression tag
Gly 8	-	expression tag
Ser 9	-	expression tag
Glu 10	-	expression tag
Asn 11	-	expression tag
Leu 12	-	expression tag
Tyr 13	-	expression tag
Phe 14	-	expression tag
Gln 15	-	expression tag
Gly 16	-	expression tag
Gly 17	-	expression tag
Ser 18	-	expression tag
Thr 19	-	expression tag
Gly 20	-	expression tag
Gly 21	-	expression tag

B, D: 22 - 839 (UniProt: P48357)

PDB	External Database	Details
Ser 840	-	expression tag
Thr 841	-	expression tag
Gly 842	-	expression tag
Gly 843	-	expression tag
Ser 844	-	expression tag
Gly 845	-	expression tag
Gly 846	-	expression tag
Ser 847	-	expression tag
Gly 848	-	expression tag
Gly 849	-	expression tag
Ser 850	-	expression tag
Gly 851	-	expression tag
Gly 852	-	expression tag
Ser 853	-	expression tag
Gly 854	-	expression tag
Gly 855	-	expression tag
Ser 856	-	expression tag
Arg 857	-	expression tag
Met 858	-	expression tag
Lys 859	-	expression tag
Gln 860	-	expression tag
Ile 861	-	expression tag
Glu 862	-	expression tag
Asp 863	-	expression tag
Lys 864	-	expression tag
Ile 865	-	expression tag
Glu 866	-	expression tag
Glu 867	-	expression tag
Ile 868	-	expression tag
Leu 869	-	expression tag
Ser 870	-	expression tag
Lys 871	-	expression tag
Ile 872	-	expression tag
Tyr 873	-	expression tag
His 874	-	expression tag
Ile 875	-	expression tag
Glu 876	-	expression tag
Asn 877	-	expression tag
Glu 878	-	expression tag
Ile 879	-	expression tag
Ala 880	-	expression tag
Arg 881	-	expression tag
Ile 882	-	expression tag
Lys 883	-	expression tag
Lys 884	-	expression tag
Leu 885	-	expression tag
Ile 886	-	expression tag
Gly 887	-	expression tag
Glu 888	-	expression tag
Arg 889	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	234854.2
All*	Total formula weight	234854.2

*Water molecules are not included.