Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8AVE

Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001525	biological_process	angiogenesis
A	0001542	biological_process	ovulation from ovarian follicle
A	0001666	biological_process	response to hypoxia
A	0001819	biological_process	positive regulation of cytokine production
A	0001890	biological_process	placenta development
A	0001936	biological_process	regulation of endothelial cell proliferation
A	0002021	biological_process	response to dietary excess
A	0003300	biological_process	cardiac muscle hypertrophy
A	0003677	molecular_function	DNA binding
A	0005102	molecular_function	signaling receptor binding
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006112	biological_process	energy reserve metabolic process
A	0006114	biological_process	glycerol biosynthetic process
A	0006629	biological_process	lipid metabolic process
A	0006909	biological_process	phagocytosis
A	0007165	biological_process	signal transduction
A	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
A	0007565	biological_process	female pregnancy
A	0007584	biological_process	response to nutrient
A	0007623	biological_process	circadian rhythm
A	0008217	biological_process	regulation of blood pressure
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008343	biological_process	adult feeding behavior
A	0009062	biological_process	fatty acid catabolic process
A	0009892	biological_process	negative regulation of metabolic process
A	0010507	biological_process	negative regulation of autophagy
A	0010888	biological_process	negative regulation of lipid storage
A	0014823	biological_process	response to activity
A	0019953	biological_process	sexual reproduction
A	0030217	biological_process	T cell differentiation
A	0031667	biological_process	response to nutrient levels
A	0032008	biological_process	positive regulation of TOR signaling
A	0032099	biological_process	negative regulation of appetite
A	0032310	biological_process	prostaglandin secretion
A	0032355	biological_process	response to estradiol
A	0032735	biological_process	positive regulation of interleukin-12 production
A	0032755	biological_process	positive regulation of interleukin-6 production
A	0032757	biological_process	positive regulation of interleukin-8 production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0032814	biological_process	regulation of natural killer cell activation
A	0032817	biological_process	regulation of natural killer cell proliferation
A	0032868	biological_process	response to insulin
A	0033197	biological_process	response to vitamin E
A	0033210	biological_process	leptin-mediated signaling pathway
A	0033686	biological_process	positive regulation of luteinizing hormone secretion
A	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
A	0035556	biological_process	intracellular signal transduction
A	0035630	biological_process	bone mineralization involved in bone maturation
A	0038108	biological_process	negative regulation of appetite by leptin-mediated signaling pathway
A	0042102	biological_process	positive regulation of T cell proliferation
A	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
A	0042307	biological_process	positive regulation of protein import into nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0043270	biological_process	positive regulation of monoatomic ion transport
A	0043410	biological_process	positive regulation of MAPK cascade
A	0044320	biological_process	cellular response to leptin stimulus
A	0045471	biological_process	response to ethanol
A	0045765	biological_process	regulation of angiogenesis
A	0045906	biological_process	negative regulation of vasoconstriction
A	0046325	biological_process	negative regulation of D-glucose import
A	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
A	0046628	biological_process	positive regulation of insulin receptor signaling pathway
A	0046850	biological_process	regulation of bone remodeling
A	0046881	biological_process	positive regulation of follicle-stimulating hormone secretion
A	0048639	biological_process	positive regulation of developmental growth
A	0050892	biological_process	intestinal absorption
A	0050901	biological_process	leukocyte tethering or rolling
A	0050999	biological_process	regulation of nitric-oxide synthase activity
A	0051051	biological_process	negative regulation of transport
A	0051428	molecular_function	peptide hormone receptor binding
A	0051726	biological_process	regulation of cell cycle
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0060587	biological_process	regulation of lipoprotein lipid oxidation
A	0061037	biological_process	negative regulation of cartilage development
A	0070093	biological_process	negative regulation of glucagon secretion
A	0071298	biological_process	cellular response to L-ascorbic acid
A	0071300	biological_process	cellular response to retinoic acid
A	0090335	biological_process	regulation of brown fat cell differentiation
A	0097009	biological_process	energy homeostasis
A	0097696	biological_process	cell surface receptor signaling pathway via STAT
A	0098868	biological_process	bone growth
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	1900015	biological_process	regulation of cytokine production involved in inflammatory response
A	1900745	biological_process	positive regulation of p38MAPK cascade
A	1904651	biological_process	positive regulation of fat cell apoptotic process
A	1990051	biological_process	activation of protein kinase C activity
A	1990460	molecular_function	leptin receptor binding
A	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
A	2000486	biological_process	negative regulation of glutamine transport
A	2000491	biological_process	positive regulation of hepatic stellate cell activation
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0004896	molecular_function	cytokine receptor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0016020	cellular_component	membrane
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0001525	biological_process	angiogenesis
C	0001542	biological_process	ovulation from ovarian follicle
C	0001666	biological_process	response to hypoxia
C	0001819	biological_process	positive regulation of cytokine production
C	0001890	biological_process	placenta development
C	0001936	biological_process	regulation of endothelial cell proliferation
C	0002021	biological_process	response to dietary excess
C	0003300	biological_process	cardiac muscle hypertrophy
C	0003677	molecular_function	DNA binding
C	0005102	molecular_function	signaling receptor binding
C	0005179	molecular_function	hormone activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006112	biological_process	energy reserve metabolic process
C	0006114	biological_process	glycerol biosynthetic process
C	0006629	biological_process	lipid metabolic process
C	0006909	biological_process	phagocytosis
C	0007165	biological_process	signal transduction
C	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
C	0007565	biological_process	female pregnancy
C	0007584	biological_process	response to nutrient
C	0007623	biological_process	circadian rhythm
C	0008217	biological_process	regulation of blood pressure
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008343	biological_process	adult feeding behavior
C	0009062	biological_process	fatty acid catabolic process
C	0009892	biological_process	negative regulation of metabolic process
C	0010507	biological_process	negative regulation of autophagy
C	0010888	biological_process	negative regulation of lipid storage
C	0014823	biological_process	response to activity
C	0019953	biological_process	sexual reproduction
C	0030217	biological_process	T cell differentiation
C	0031667	biological_process	response to nutrient levels
C	0032008	biological_process	positive regulation of TOR signaling
C	0032099	biological_process	negative regulation of appetite
C	0032310	biological_process	prostaglandin secretion
C	0032355	biological_process	response to estradiol
C	0032735	biological_process	positive regulation of interleukin-12 production
C	0032755	biological_process	positive regulation of interleukin-6 production
C	0032757	biological_process	positive regulation of interleukin-8 production
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0032814	biological_process	regulation of natural killer cell activation
C	0032817	biological_process	regulation of natural killer cell proliferation
C	0032868	biological_process	response to insulin
C	0033197	biological_process	response to vitamin E
C	0033210	biological_process	leptin-mediated signaling pathway
C	0033686	biological_process	positive regulation of luteinizing hormone secretion
C	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
C	0035556	biological_process	intracellular signal transduction
C	0035630	biological_process	bone mineralization involved in bone maturation
C	0038108	biological_process	negative regulation of appetite by leptin-mediated signaling pathway
C	0042102	biological_process	positive regulation of T cell proliferation
C	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
C	0042307	biological_process	positive regulation of protein import into nucleus
C	0043066	biological_process	negative regulation of apoptotic process
C	0043270	biological_process	positive regulation of monoatomic ion transport
C	0043410	biological_process	positive regulation of MAPK cascade
C	0044320	biological_process	cellular response to leptin stimulus
C	0045471	biological_process	response to ethanol
C	0045765	biological_process	regulation of angiogenesis
C	0045906	biological_process	negative regulation of vasoconstriction
C	0046325	biological_process	negative regulation of D-glucose import
C	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
C	0046628	biological_process	positive regulation of insulin receptor signaling pathway
C	0046850	biological_process	regulation of bone remodeling
C	0046881	biological_process	positive regulation of follicle-stimulating hormone secretion
C	0048639	biological_process	positive regulation of developmental growth
C	0050892	biological_process	intestinal absorption
C	0050901	biological_process	leukocyte tethering or rolling
C	0050999	biological_process	regulation of nitric-oxide synthase activity
C	0051051	biological_process	negative regulation of transport
C	0051428	molecular_function	peptide hormone receptor binding
C	0051726	biological_process	regulation of cell cycle
C	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0060587	biological_process	regulation of lipoprotein lipid oxidation
C	0061037	biological_process	negative regulation of cartilage development
C	0070093	biological_process	negative regulation of glucagon secretion
C	0071298	biological_process	cellular response to L-ascorbic acid
C	0071300	biological_process	cellular response to retinoic acid
C	0090335	biological_process	regulation of brown fat cell differentiation
C	0097009	biological_process	energy homeostasis
C	0097696	biological_process	cell surface receptor signaling pathway via STAT
C	0098868	biological_process	bone growth
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	1900015	biological_process	regulation of cytokine production involved in inflammatory response
C	1900745	biological_process	positive regulation of p38MAPK cascade
C	1904651	biological_process	positive regulation of fat cell apoptotic process
C	1990051	biological_process	activation of protein kinase C activity
C	1990460	molecular_function	leptin receptor binding
C	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
C	2000486	biological_process	negative regulation of glutamine transport
C	2000491	biological_process	positive regulation of hepatic stellate cell activation
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0004896	molecular_function	cytokine receptor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS01353
Number of Residues	57
Details	HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NsigaSvanfnltfswpmskvnivqslsayplnsscvi...VsWilsPsdyklmy..Fi.IeW

Chain	Residue	Details
B	ASN718-TRP774

site_id	PS01355
Number of Residues	31
Details	HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. IlpgssyevqVRgkrldgpgi...........WSdWStprvF

Chain	Residue	Details
B	ILE298-PHE328

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	188
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	196
Details	Domain: {"description":"Ig-like"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	190
Details	Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	186
Details	Domain: {"description":"Fibronectin type-III 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	34
Details	Region: {"description":"Leptin-binding","evidences":[{"source":"PubMed","id":"22405007","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9786864","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	14
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"9786864","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9786864","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9786864","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)