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8AVE

Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001525biological_processangiogenesis
A0001542biological_processovulation from ovarian follicle
A0001666biological_processresponse to hypoxia
A0001819biological_processpositive regulation of cytokine production
A0001890biological_processplacenta development
A0001934biological_processpositive regulation of protein phosphorylation
A0001936biological_processregulation of endothelial cell proliferation
A0002021biological_processresponse to dietary excess
A0003300biological_processcardiac muscle hypertrophy
A0003677molecular_functionDNA binding
A0005102molecular_functionsignaling receptor binding
A0005179molecular_functionhormone activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006111biological_processregulation of gluconeogenesis
A0006112biological_processenergy reserve metabolic process
A0006114biological_processglycerol biosynthetic process
A0006629biological_processlipid metabolic process
A0006635biological_processfatty acid beta-oxidation
A0006909biological_processphagocytosis
A0007165biological_processsignal transduction
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0007565biological_processfemale pregnancy
A0007584biological_processresponse to nutrient
A0007623biological_processcircadian rhythm
A0008203biological_processcholesterol metabolic process
A0008206biological_processbile acid metabolic process
A0008217biological_processregulation of blood pressure
A0008284biological_processpositive regulation of cell population proliferation
A0008340biological_processdetermination of adult lifespan
A0008343biological_processadult feeding behavior
A0009062biological_processfatty acid catabolic process
A0009892biological_processnegative regulation of metabolic process
A0010507biological_processnegative regulation of autophagy
A0010888biological_processnegative regulation of lipid storage
A0014823biological_processresponse to activity
A0019222biological_processregulation of metabolic process
A0019953biological_processsexual reproduction
A0021954biological_processcentral nervous system neuron development
A0030073biological_processinsulin secretion
A0030217biological_processT cell differentiation
A0030300biological_processregulation of intestinal cholesterol absorption
A0031667biological_processresponse to nutrient levels
A0032008biological_processpositive regulation of TOR signaling
A0032099biological_processnegative regulation of appetite
A0032310biological_processprostaglandin secretion
A0032355biological_processresponse to estradiol
A0032735biological_processpositive regulation of interleukin-12 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032757biological_processpositive regulation of interleukin-8 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032814biological_processregulation of natural killer cell activation
A0032817biological_processregulation of natural killer cell proliferation
A0032868biological_processresponse to insulin
A0032869biological_processcellular response to insulin stimulus
A0033197biological_processresponse to vitamin E
A0033210biological_processleptin-mediated signaling pathway
A0033686biological_processpositive regulation of luteinizing hormone secretion
A0035360biological_processpositive regulation of peroxisome proliferator activated receptor signaling pathway
A0035556biological_processintracellular signal transduction
A0035630biological_processbone mineralization involved in bone maturation
A0035904biological_processaorta development
A0038108biological_processnegative regulation of appetite by leptin-mediated signaling pathway
A0042102biological_processpositive regulation of T cell proliferation
A0042269biological_processregulation of natural killer cell mediated cytotoxicity
A0042307biological_processpositive regulation of protein import into nucleus
A0042445biological_processhormone metabolic process
A0042593biological_processglucose homeostasis
A0042755biological_processeating behavior
A0043066biological_processnegative regulation of apoptotic process
A0043270biological_processpositive regulation of monoatomic ion transport
A0043410biological_processpositive regulation of MAPK cascade
A0044320biological_processcellular response to leptin stimulus
A0045471biological_processresponse to ethanol
A0045598biological_processregulation of fat cell differentiation
A0045765biological_processregulation of angiogenesis
A0045906biological_processnegative regulation of vasoconstriction
A0046325biological_processnegative regulation of D-glucose import
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046628biological_processpositive regulation of insulin receptor signaling pathway
A0046850biological_processregulation of bone remodeling
A0046881biological_processpositive regulation of follicle-stimulating hormone secretion
A0046890biological_processregulation of lipid biosynthetic process
A0048639biological_processpositive regulation of developmental growth
A0050796biological_processregulation of insulin secretion
A0050810biological_processregulation of steroid biosynthetic process
A0050892biological_processintestinal absorption
A0050901biological_processleukocyte tethering or rolling
A0050999biological_processregulation of nitric-oxide synthase activity
A0051428molecular_functionpeptide hormone receptor binding
A0051541biological_processelastin metabolic process
A0051726biological_processregulation of cell cycle
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060587biological_processregulation of lipoprotein lipid oxidation
A0060612biological_processadipose tissue development
A0061037biological_processnegative regulation of cartilage development
A0070093biological_processnegative regulation of glucagon secretion
A0071298biological_processcellular response to L-ascorbic acid
A0071300biological_processcellular response to retinoic acid
A0090335biological_processregulation of brown fat cell differentiation
A0097009biological_processenergy homeostasis
A0098868biological_processbone growth
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1900015biological_processregulation of cytokine production involved in inflammatory response
A1900180biological_processregulation of protein localization to nucleus
A1900745biological_processpositive regulation of p38MAPK cascade
A1904651biological_processpositive regulation of fat cell apoptotic process
A1990051biological_processactivation of protein kinase C activity
A1990460molecular_functionleptin receptor binding
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
A2000486biological_processnegative regulation of glutamine transport
A2000491biological_processpositive regulation of hepatic stellate cell activation
B0003700molecular_functionDNA-binding transcription factor activity
B0004896molecular_functioncytokine receptor activity
B0006355biological_processregulation of DNA-templated transcription
B0016020cellular_componentmembrane
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001525biological_processangiogenesis
C0001542biological_processovulation from ovarian follicle
C0001666biological_processresponse to hypoxia
C0001819biological_processpositive regulation of cytokine production
C0001890biological_processplacenta development
C0001934biological_processpositive regulation of protein phosphorylation
C0001936biological_processregulation of endothelial cell proliferation
C0002021biological_processresponse to dietary excess
C0003300biological_processcardiac muscle hypertrophy
C0003677molecular_functionDNA binding
C0005102molecular_functionsignaling receptor binding
C0005179molecular_functionhormone activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006006biological_processglucose metabolic process
C0006111biological_processregulation of gluconeogenesis
C0006112biological_processenergy reserve metabolic process
C0006114biological_processglycerol biosynthetic process
C0006629biological_processlipid metabolic process
C0006635biological_processfatty acid beta-oxidation
C0006909biological_processphagocytosis
C0007165biological_processsignal transduction
C0007259biological_processcell surface receptor signaling pathway via JAK-STAT
C0007565biological_processfemale pregnancy
C0007584biological_processresponse to nutrient
C0007623biological_processcircadian rhythm
C0008203biological_processcholesterol metabolic process
C0008206biological_processbile acid metabolic process
C0008217biological_processregulation of blood pressure
C0008284biological_processpositive regulation of cell population proliferation
C0008340biological_processdetermination of adult lifespan
C0008343biological_processadult feeding behavior
C0009062biological_processfatty acid catabolic process
C0009892biological_processnegative regulation of metabolic process
C0010507biological_processnegative regulation of autophagy
C0010888biological_processnegative regulation of lipid storage
C0014823biological_processresponse to activity
C0019222biological_processregulation of metabolic process
C0019953biological_processsexual reproduction
C0021954biological_processcentral nervous system neuron development
C0030073biological_processinsulin secretion
C0030217biological_processT cell differentiation
C0030300biological_processregulation of intestinal cholesterol absorption
C0031667biological_processresponse to nutrient levels
C0032008biological_processpositive regulation of TOR signaling
C0032099biological_processnegative regulation of appetite
C0032310biological_processprostaglandin secretion
C0032355biological_processresponse to estradiol
C0032735biological_processpositive regulation of interleukin-12 production
C0032755biological_processpositive regulation of interleukin-6 production
C0032757biological_processpositive regulation of interleukin-8 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0032814biological_processregulation of natural killer cell activation
C0032817biological_processregulation of natural killer cell proliferation
C0032868biological_processresponse to insulin
C0032869biological_processcellular response to insulin stimulus
C0033197biological_processresponse to vitamin E
C0033210biological_processleptin-mediated signaling pathway
C0033686biological_processpositive regulation of luteinizing hormone secretion
C0035360biological_processpositive regulation of peroxisome proliferator activated receptor signaling pathway
C0035556biological_processintracellular signal transduction
C0035630biological_processbone mineralization involved in bone maturation
C0035904biological_processaorta development
C0038108biological_processnegative regulation of appetite by leptin-mediated signaling pathway
C0042102biological_processpositive regulation of T cell proliferation
C0042269biological_processregulation of natural killer cell mediated cytotoxicity
C0042307biological_processpositive regulation of protein import into nucleus
C0042445biological_processhormone metabolic process
C0042593biological_processglucose homeostasis
C0042755biological_processeating behavior
C0043066biological_processnegative regulation of apoptotic process
C0043270biological_processpositive regulation of monoatomic ion transport
C0043410biological_processpositive regulation of MAPK cascade
C0044320biological_processcellular response to leptin stimulus
C0045471biological_processresponse to ethanol
C0045598biological_processregulation of fat cell differentiation
C0045765biological_processregulation of angiogenesis
C0045906biological_processnegative regulation of vasoconstriction
C0046325biological_processnegative regulation of D-glucose import
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046628biological_processpositive regulation of insulin receptor signaling pathway
C0046850biological_processregulation of bone remodeling
C0046881biological_processpositive regulation of follicle-stimulating hormone secretion
C0046890biological_processregulation of lipid biosynthetic process
C0048639biological_processpositive regulation of developmental growth
C0050796biological_processregulation of insulin secretion
C0050810biological_processregulation of steroid biosynthetic process
C0050892biological_processintestinal absorption
C0050901biological_processleukocyte tethering or rolling
C0050999biological_processregulation of nitric-oxide synthase activity
C0051428molecular_functionpeptide hormone receptor binding
C0051541biological_processelastin metabolic process
C0051726biological_processregulation of cell cycle
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0060587biological_processregulation of lipoprotein lipid oxidation
C0060612biological_processadipose tissue development
C0061037biological_processnegative regulation of cartilage development
C0070093biological_processnegative regulation of glucagon secretion
C0071298biological_processcellular response to L-ascorbic acid
C0071300biological_processcellular response to retinoic acid
C0090335biological_processregulation of brown fat cell differentiation
C0097009biological_processenergy homeostasis
C0098868biological_processbone growth
C0120162biological_processpositive regulation of cold-induced thermogenesis
C1900015biological_processregulation of cytokine production involved in inflammatory response
C1900180biological_processregulation of protein localization to nucleus
C1900745biological_processpositive regulation of p38MAPK cascade
C1904651biological_processpositive regulation of fat cell apoptotic process
C1990051biological_processactivation of protein kinase C activity
C1990460molecular_functionleptin receptor binding
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
C2000486biological_processnegative regulation of glutamine transport
C2000491biological_processpositive regulation of hepatic stellate cell activation
D0003700molecular_functionDNA-binding transcription factor activity
D0004896molecular_functioncytokine receptor activity
D0006355biological_processregulation of DNA-templated transcription
D0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS01353
Number of Residues57
DetailsHEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NsigaSvanfnltfswpmskvnivqslsayplnsscvi...VsWilsPsdyklmy..Fi.IeW
ChainResidueDetails
BASN718-TRP774

site_idPS01355
Number of Residues31
DetailsHEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. IlpgssyevqVRgkrldgpgi...........WSdWStprvF
ChainResidueDetails
BILE298-PHE328

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1634
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BPHE22-ASP839
DPHE22-ASP839

site_idSWS_FT_FI2
Number of Residues30
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:9786864
ChainResidueDetails
BASN23
BASN624
BASN659
BASN688
BASN697
BASN728
BASN750
DASN23
DASN41
DASN56
DASN73
BASN41
DASN81
DASN98
DASN187
DASN206
DASN347
DASN624
DASN659
DASN688
DASN697
DASN728
BASN56
DASN750
BASN73
BASN81
BASN98
BASN187
BASN206
BASN347

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9786864
ChainResidueDetails
BASN276
DASN276

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9786864
ChainResidueDetails
BASN397
DASN397

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:9786864
ChainResidueDetails
BASN516
DASN516

226707

PDB entries from 2024-10-30

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