8OE4

Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex.

Summary for 8OE4

• Entry DOI: 10.2210/pdb8oe4/pdb
• Related: 8c7m 8cr5 8cr6 8cr8 8odx 8odz 8oe0
• EMDB information: 16820 16821 16822 16823 16824
• Descriptor: Interleukin-12 subunit beta, Interleukin-23 subunit alpha, Interleukin-23 receptor,Calmodulin-1, ... (7 entities in total)
• Functional Keywords: complex, cytokine, receptor, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 172185.25

Authors

Bloch, Y.,Felix, J.,Savvides, S.N. (deposition date: 2023-03-10, release date: 2024-02-07)

• Primary citation: Bloch, Y.,Felix, J.,Merceron, R.,Provost, M.,Symakani, R.A.,De Backer, R.,Lambert, E.,Mehdipour, A.R.,Savvides, S.N.; Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.; Nat.Struct.Mol.Biol., 2024; PubMed: 38287195; DOI: 10.1038/s41594-023-01190-6

Experimental method

ELECTRON MICROSCOPY (3.6 Å)