8C7M

Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb fragment.

Summary for 8C7M

Entry DOI	10.2210/pdb8c7m/pdb
Descriptor	Interleukin-12 receptor subunit beta-1, FAb4 Heavy chain, FAb4 Crystal Kappa Light chain, ... (6 entities in total)
Functional Keywords	receptor, antagonist, antibody, cytokine
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	165742.31
Authors	Bloch, Y.,Savvides, S.N. (deposition date: 2023-01-16, release date: 2024-01-31, Last modification date: 2024-05-01)
Primary citation	Bloch, Y.,Felix, J.,Merceron, R.,Provost, M.,Symakani, R.A.,De Backer, R.,Lambert, E.,Mehdipour, A.R.,Savvides, S.N. Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31:591-597, 2024 Cited by PubMed: 38287195 DOI: 10.1038/s41594-023-01190-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.56 Å)

Structure validation