8C7M
Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb fragment.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Interleukin-12 receptor subunit beta-1 | polymer | 313 | 34256.4 | 2 | UniProt (P42701) Pfam (PF00041) | Homo sapiens (human) | IL-12 receptor subunit beta-1,IL-12R subunit beta-1,IL-12R-beta-1,IL-12RB1,IL-12 receptor beta component |
| 2 | C, E (C, H) | FAb4 Heavy chain | polymer | 231 | 24786.6 | 2 | Homo sapiens x Mus musculus hybrid cell line | ||
| 3 | D, F (D, L) | FAb4 Crystal Kappa Light chain | polymer | 212 | 23239.7 | 2 | Homo sapiens x Mus musculus hybrid cell line | ||
| 4 | G, H, I, J, L (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 5 | K, M (A, H) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | N, O, P, Q, R (A, B, C, H, L) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A, B: 232 - 540 (UniProt: P42701)
| PDB | External Database | Details |
|---|---|---|
| Asp 541 | - | expression tag |
| Glu 542 | - | expression tag |
| Val 543 | - | expression tag |
| Asp 544 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 164565.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1176.9 | |
| All* | Total formula weight | 165742.3 |
