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8OE4

Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex.

Functional Information from GO Data
ChainGOidnamespacecontents
A0001817biological_processregulation of cytokine production
A0001916biological_processpositive regulation of T cell mediated cytotoxicity
A0002230biological_processpositive regulation of defense response to virus by host
A0002323biological_processnatural killer cell activation involved in immune response
A0002827biological_processpositive regulation of T-helper 1 type immune response
A0002860biological_processpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0004896molecular_functioncytokine receptor activity
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005143molecular_functioninterleukin-12 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005829cellular_componentcytosol
A0007166biological_processcell surface receptor signaling pathway
A0008083molecular_functiongrowth factor activity
A0008283biological_processcell population proliferation
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010033biological_processresponse to organic substance
A0010224biological_processresponse to UV-B
A0010536biological_processpositive regulation of activation of Janus kinase activity
A0016477biological_processcell migration
A0019221biological_processcytokine-mediated signaling pathway
A0019953biological_processsexual reproduction
A0019955molecular_functioncytokine binding
A0030101biological_processnatural killer cell activation
A0031906cellular_componentlate endosome lumen
A0032693biological_processnegative regulation of interleukin-10 production
A0032700biological_processnegative regulation of interleukin-17 production
A0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
A0032729biological_processpositive regulation of type II interferon production
A0032733biological_processpositive regulation of interleukin-10 production
A0032735biological_processpositive regulation of interleukin-12 production
A0032740biological_processpositive regulation of interleukin-17 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032816biological_processpositive regulation of natural killer cell activation
A0032819biological_processpositive regulation of natural killer cell proliferation
A0032946biological_processpositive regulation of mononuclear cell proliferation
A0034105biological_processpositive regulation of tissue remodeling
A0034393biological_processpositive regulation of smooth muscle cell apoptotic process
A0035722biological_processinterleukin-12-mediated signaling pathway
A0042088biological_processT-helper 1 type immune response
A0042093biological_processT-helper cell differentiation
A0042098biological_processT cell proliferation
A0042102biological_processpositive regulation of T cell proliferation
A0042104biological_processpositive regulation of activated T cell proliferation
A0042164molecular_functioninterleukin-12 alpha subunit binding
A0042509biological_processregulation of tyrosine phosphorylation of STAT protein
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0042802molecular_functionidentical protein binding
A0042832biological_processdefense response to protozoan
A0043235cellular_componentreceptor complex
A0043382biological_processpositive regulation of memory T cell differentiation
A0043514cellular_componentinterleukin-12 complex
A0044877molecular_functionprotein-containing complex binding
A0045519molecular_functioninterleukin-23 receptor binding
A0045672biological_processpositive regulation of osteoclast differentiation
A0045785biological_processpositive regulation of cell adhesion
A0046982molecular_functionprotein heterodimerization activity
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0050671biological_processpositive regulation of lymphocyte proliferation
A0050709biological_processnegative regulation of protein secretion
A0050729biological_processpositive regulation of inflammatory response
A0050829biological_processdefense response to Gram-negative bacterium
A0051135biological_processpositive regulation of NK T cell activation
A0051142biological_processpositive regulation of NK T cell proliferation
A0051607biological_processdefense response to virus
A0070743cellular_componentinterleukin-23 complex
A0071222biological_processcellular response to lipopolysaccharide
A0071346biological_processcellular response to type II interferon
A1900747biological_processnegative regulation of vascular endothelial growth factor signaling pathway
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A1903588biological_processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
A2000318biological_processpositive regulation of T-helper 17 type immune response
A2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002230biological_processpositive regulation of defense response to virus by host
B0002827biological_processpositive regulation of T-helper 1 type immune response
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005788cellular_componentendoplasmic reticulum lumen
B0006954biological_processinflammatory response
B0007165biological_processsignal transduction
B0010536biological_processpositive regulation of activation of Janus kinase activity
B0032693biological_processnegative regulation of interleukin-10 production
B0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
B0032729biological_processpositive regulation of type II interferon production
B0032733biological_processpositive regulation of interleukin-10 production
B0032735biological_processpositive regulation of interleukin-12 production
B0032740biological_processpositive regulation of interleukin-17 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0032816biological_processpositive regulation of natural killer cell activation
B0032819biological_processpositive regulation of natural killer cell proliferation
B0034105biological_processpositive regulation of tissue remodeling
B0042098biological_processT cell proliferation
B0042102biological_processpositive regulation of T cell proliferation
B0042104biological_processpositive regulation of activated T cell proliferation
B0042509biological_processregulation of tyrosine phosphorylation of STAT protein
B0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
B0043382biological_processpositive regulation of memory T cell differentiation
B0045087biological_processinnate immune response
B0045519molecular_functioninterleukin-23 receptor binding
B0045672biological_processpositive regulation of osteoclast differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048771biological_processtissue remodeling
B0050729biological_processpositive regulation of inflammatory response
B0050829biological_processdefense response to Gram-negative bacterium
B0051135biological_processpositive regulation of NK T cell activation
B0051142biological_processpositive regulation of NK T cell proliferation
B0051607biological_processdefense response to virus
B0070743cellular_componentinterleukin-23 complex
B0090023biological_processpositive regulation of neutrophil chemotaxis
B1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
B2000318biological_processpositive regulation of T-helper 17 type immune response
B2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
C0000086biological_processG2/M transition of mitotic cell cycle
C0000922cellular_componentspindle pole
C0002027biological_processregulation of heart rate
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005876cellular_componentspindle microtubule
C0005886cellular_componentplasma membrane
C0007186biological_processG protein-coupled receptor signaling pathway
C0008076cellular_componentvoltage-gated potassium channel complex
C0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
C0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
C0010856molecular_functionadenylate cyclase activator activity
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0016020cellular_componentmembrane
C0016240biological_processautophagosome membrane docking
C0019855molecular_functioncalcium channel inhibitor activity
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030017cellular_componentsarcomere
C0031432molecular_functiontitin binding
C0031514cellular_componentmotile cilium
C0031954biological_processpositive regulation of protein autophosphorylation
C0031982cellular_componentvesicle
C0032465biological_processregulation of cytokinesis
C0032516biological_processpositive regulation of phosphoprotein phosphatase activity
C0032991cellular_componentprotein-containing complex
C0034704cellular_componentcalcium channel complex
C0035307biological_processpositive regulation of protein dephosphorylation
C0035458biological_processcellular response to interferon-beta
C0043209cellular_componentmyelin sheath
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0044325molecular_functiontransmembrane transporter binding
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050848biological_processregulation of calcium-mediated signaling
C0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
C0051592biological_processresponse to calcium ion
C0055117biological_processregulation of cardiac muscle contraction
C0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
C0071346biological_processcellular response to type II interferon
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0072542molecular_functionprotein phosphatase activator activity
C0097225cellular_componentsperm midpiece
C0098901biological_processregulation of cardiac muscle cell action potential
C0140056biological_processorganelle localization by membrane tethering
C1901842biological_processnegative regulation of high voltage-gated calcium channel activity
C1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
C1902494cellular_componentcatalytic complex
C1905913biological_processnegative regulation of calcium ion export across plasma membrane
C1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PROSITE/UniProt
site_idPS00092
Number of Residues7
DetailsN6_MTASE N-6 Adenine-specific DNA methylases signature. CFQDPPY
ChainResidueDetails
DCYS30-TYR36

site_idPS01353
Number of Residues57
DetailsHEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NvaviSsnqfgpglnqtwhipadthtepvalnisvgtngttMyW...Paraqsmt..Yc.IeW
ChainResidueDetails
DASN315-TRP371

site_idPS01354
Number of Residues43
DetailsHEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. IkPDPPknLqlkplknsrq.VevsWeyPdTWstphsyFsLtFcV
ChainResidueDetails
AILE233-VAL275

site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
CASP380-LEU392
CASP416-PHE428
CASP453-LEU465
CASP489-PHE501

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
DASN121
DASN329
DASN346
DASN352
DASN442
DASN456

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:11579085, ECO:0000269|PubMed:15729359, ECO:0000269|PubMed:17056602
ChainResidueDetails
DSER559
CASN81
CASN141
CASN232
CASN262

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER570

site_idSWS_FT_FI4
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
ChainResidueDetails
CASP380
CASP382
CASP384
CTHR386
CGLU391
CASP416
CASP418
CASN420
CTHR422
CGLU427

site_idSWS_FT_FI5
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
ChainResidueDetails
CASP453
CASP455
CASN457
CTYR459
CGLU464
CASP489
CASP491
CASP493
CGLN495
CGLU500

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS381

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29
ChainResidueDetails
CTHR404

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER441

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS454

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
CTYR459

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
CSER461

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
CTHR470

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
CLYS475

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
CTYR498

site_idSWS_FT_FI15
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
CLYS381

219869

PDB entries from 2024-05-15

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