8OE4
Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Interleukin-12 subunit beta | polymer | 306 | 34740.9 | 1 | UniProt (P29460) Pfam (PF10420) In PDB | Homo sapiens (human) | IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,NKSF2 |
2 | B | Interleukin-23 subunit alpha | polymer | 186 | 20650.1 | 1 | UniProt (Q9NPF7) Pfam (PF16649) In PDB | Homo sapiens (human) | IL-23 subunit alpha,IL-23-A,Interleukin-23 subunit p19,IL-23p19 |
3 | C | Interleukin-23 receptor,Calmodulin-1 | polymer | 485 | 54991.4 | 1 | UniProt (Q5VWK5) UniProt (P0DP23) Pfam (PF13499) In PDB | Homo sapiens (human) | IL-23 receptor,IL-23R |
4 | D | Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1 | polymer | 547 | 60187.3 | 1 | UniProt (P42701) UniProt (P53355) Pfam (PF00041) In PDB | Homo sapiens (human) | IL-12 receptor subunit beta-1,IL-12R subunit beta-1,IL-12R-beta-1,IL-12RB1,IL-12 receptor beta component,DAP kinase 1 |
5 | E | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
6 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
7 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A: 23 - 328 (UniProt: P29460)
B: 20 - 189 (UniProt: Q9NPF7)
C: 24 - 353 (UniProt: Q5VWK5)
C: 364 - 508 (UniProt: P0DP23)
D: 24 - 540 (UniProt: P42701)
D: 552 - 570 (UniProt: P53355)
PDB | External Database | Details |
---|---|---|
Asp 303 | Asn 303 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 190 | - | expression tag |
Asp 191 | - | expression tag |
Glu 192 | - | expression tag |
Val 193 | - | expression tag |
Asp 194 | - | expression tag |
Gly 195 | - | expression tag |
His 196 | - | expression tag |
His 197 | - | expression tag |
His 198 | - | expression tag |
His 199 | - | expression tag |
His 200 | - | expression tag |
His 201 | - | expression tag |
His 202 | - | expression tag |
His 203 | - | expression tag |
His 204 | - | expression tag |
His 205 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 354 | - | linker |
Thr 355 | - | linker |
Gly 356 | - | linker |
Gly 357 | - | linker |
Ser 358 | - | linker |
Gly 359 | - | linker |
Gly 360 | - | linker |
Ser 361 | - | linker |
Gly 362 | - | linker |
Gly 363 | - | linker |
D: 24 - 540 (UniProt: P42701)
PDB | External Database | Details |
---|---|---|
Gly 541 | - | linker |
Thr 542 | - | linker |
Gly 543 | - | linker |
Gly 544 | - | linker |
Ser 545 | - | linker |
Gly 546 | - | linker |
Gly 547 | - | linker |
Ser 548 | - | linker |
Gly 549 | - | linker |
Gly 550 | - | linker |
Ala 551 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 170569.8 | |
Branched | Number of molecules | 2 |
Total formula weight | 1173.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 442.4 | |
All* | Total formula weight | 172185.3 |