8AVF
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (closed 3:3 model)
Summary for 8AVF
Entry DOI | 10.2210/pdb8avf/pdb |
Related | 7z3q 7z3r |
EMDB information | 15681 |
Descriptor | Leptin, Leptin receptor (2 entities in total) |
Functional Keywords | leptin, lep-r, obesity, metabolism, energy balance, cytokine |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 352281.37 |
Authors | Verstraete, K.,Savvides, S.N.,Verschueren, K.G.,Tsirigotaki, A. (deposition date: 2022-08-26, release date: 2023-04-05, Last modification date: 2023-04-26) |
Primary citation | Tsirigotaki, A.,Dansercoer, A.,Verschueren, K.H.G.,Markovic, I.,Pollmann, C.,Hafer, M.,Felix, J.,Birck, C.,Van Putte, W.,Catteeuw, D.,Tavernier, J.,Fernando Bazan, J.,Piehler, J.,Savvides, S.N.,Verstraete, K. Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30:551-563, 2023 Cited by PubMed: 36959263DOI: 10.1038/s41594-023-00941-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (6.45 Å) |
Structure validation
Download full validation report