8B7Q

Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement

Summary for 8B7Q

Entry DOI	10.2210/pdb8b7q/pdb
Related	7z3r 8avd
EMDB information	15899
Descriptor	Leptin, Leptin receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	leptin, lep-r, obesity, metabolism, energy balance, cytokine
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	3
Total formula weight	214053.27
Authors	Verstraete, K.,Savvides, S.N.,Verschueren, K.G.,Tsirigotaki, A. (deposition date: 2022-09-30, release date: 2023-04-05, Last modification date: 2023-04-26)
Primary citation	Tsirigotaki, A.,Dansercoer, A.,Verschueren, K.H.G.,Markovic, I.,Pollmann, C.,Hafer, M.,Felix, J.,Birck, C.,Van Putte, W.,Catteeuw, D.,Tavernier, J.,Fernando Bazan, J.,Piehler, J.,Savvides, S.N.,Verstraete, K. Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30:551-563, 2023 Cited by PubMed: 36959263 DOI: 10.1038/s41594-023-00941-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.02 Å)

Structure validation