8B7Q
Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Leptin | polymer | 174 | 18873.3 | 1 | UniProt (P41160) Pfam (PF02024) In PDB | Mus musculus (house mouse) | Obesity factor |
2 | B, F | Leptin receptor | polymer | 868 | 97479.4 | 2 | UniProt (P48356) Pfam (PF18589) Pfam (PF00041) Pfam (PF06328) In PDB | Mus musculus (house mouse) | LEP-R,B219,OB receptor,OB-R |
3 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
A: 21 - 167 (UniProt: P41160)
B, F: 22 - 839 (UniProt: P48356)
PDB | External Database | Details |
---|---|---|
Met -6 | - | initiating methionine |
Gly -5 | - | expression tag |
Ser -4 | - | expression tag |
Ser -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
His 2 | - | expression tag |
His 3 | - | expression tag |
Pro 4 | - | expression tag |
Gly 5 | - | expression tag |
Gly 6 | - | expression tag |
Pro 7 | - | expression tag |
Gly 8 | - | expression tag |
Ser 9 | - | expression tag |
Glu 10 | - | expression tag |
Asn 11 | - | expression tag |
Leu 12 | - | expression tag |
Tyr 13 | - | expression tag |
Phe 14 | - | expression tag |
Gln 15 | - | expression tag |
Gly 16 | - | expression tag |
Gly 17 | - | expression tag |
Ser 18 | - | expression tag |
Thr 19 | - | expression tag |
Gly 20 | - | expression tag |
Gly 21 | Ala 21 | conflict |
PDB | External Database | Details |
---|---|---|
Ser 840 | - | expression tag |
Thr 841 | - | expression tag |
Gly 842 | - | expression tag |
Gly 843 | - | expression tag |
Ser 844 | - | expression tag |
Gly 845 | - | expression tag |
Gly 846 | - | expression tag |
Ser 847 | - | expression tag |
Gly 848 | - | expression tag |
Gly 849 | - | expression tag |
Ser 850 | - | expression tag |
Gly 851 | - | expression tag |
Gly 852 | - | expression tag |
Ser 853 | - | expression tag |
Gly 854 | - | expression tag |
Gly 855 | - | expression tag |
Ser 856 | - | expression tag |
Arg 857 | - | expression tag |
Met 858 | - | expression tag |
Lys 859 | - | expression tag |
Gln 860 | - | expression tag |
Ile 861 | - | expression tag |
Glu 862 | - | expression tag |
Asp 863 | - | expression tag |
Lys 864 | - | expression tag |
Ile 865 | - | expression tag |
Glu 866 | - | expression tag |
Glu 867 | - | expression tag |
Ile 868 | - | expression tag |
Leu 869 | - | expression tag |
Ser 870 | - | expression tag |
Lys 871 | - | expression tag |
Ile 872 | - | expression tag |
Tyr 873 | - | expression tag |
His 874 | - | expression tag |
Ile 875 | - | expression tag |
Glu 876 | - | expression tag |
Asn 877 | - | expression tag |
Glu 878 | - | expression tag |
Ile 879 | - | expression tag |
Ala 880 | - | expression tag |
Arg 881 | - | expression tag |
Ile 882 | - | expression tag |
Lys 883 | - | expression tag |
Lys 884 | - | expression tag |
Leu 885 | - | expression tag |
Ile 886 | - | expression tag |
Gly 887 | - | expression tag |
Glu 888 | - | expression tag |
Arg 889 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 213832.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 221.2 | |
All* | Total formula weight | 214053.3 |