8AVO

Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model).

Summary for 8AVO

Entry DOI	10.2210/pdb8avo/pdb
Related	7z3q 7z3r
EMDB information	15683
Descriptor	Leptin, Leptin receptor (2 entities in total)
Functional Keywords	leptin, lep-r, obesity, metabolism, energy balance, cytokine
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	352281.37
Authors	Verstraete, K.,Savvides, S.N.,Verschueren, K.G.,Tsirigotaki, A. (deposition date: 2022-08-26, release date: 2023-04-05, Last modification date: 2023-04-26)
Primary citation	Tsirigotaki, A.,Dansercoer, A.,Verschueren, K.H.G.,Markovic, I.,Pollmann, C.,Hafer, M.,Felix, J.,Birck, C.,Van Putte, W.,Catteeuw, D.,Tavernier, J.,Fernando Bazan, J.,Piehler, J.,Savvides, S.N.,Verstraete, K. Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30:551-563, 2023 Cited by PubMed: 36959263 DOI: 10.1038/s41594-023-00941-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (6.84 Å)

Structure validation