8AVB

Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model).

This is a non-PDB format compatible entry.

Summary for 8AVB

• Entry DOI: 10.2210/pdb8avb/pdb
• Related: 7Z3R
• EMDB information: 15677
• Descriptor: Leptin, Leptin receptor (2 entities in total)
• Functional Keywords: leptin, lep-r, obesity, metabolism, energy balance, cytokine
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 3
• Total formula weight: 204597.36

Authors

Verstraete, K.,Savvides, S.N.,Verschueren, K.G.,Tsirigotaki, A. (deposition date: 2022-08-26, release date: 2023-04-05, Last modification date: 2023-07-26)

• Primary citation: Tsirigotaki, A.,Dansercoer, A.,Verschueren, K.H.G.,Markovic, I.,Pollmann, C.,Hafer, M.,Felix, J.,Birck, C.,Van Putte, W.,Catteeuw, D.,Tavernier, J.,Fernando Bazan, J.,Piehler, J.,Savvides, S.N.,Verstraete, K.; Mechanism of receptor assembly via the pleiotropic adipokine Leptin.; Nat.Struct.Mol.Biol., 30:551-563, 2023; PubMed: 36959263; DOI: 10.1038/s41594-023-00941-9

Experimental method

ELECTRON MICROSCOPY (4.43 Å)