8AVB

Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model).

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Leptin	polymer	152	16434.7	1	UniProt (P41160) Pfam (PF02024)	Mus musculus (house mouse)	Obesity factor
2	B, C (B, F)	Leptin receptor	polymer	835	94081.3	2	UniProt (P48356) Pfam (PF18589) Pfam (PF00041) Pfam (PF06328)	Mus musculus (house mouse)	LEP-R,B219,OB receptor,OB-R

Sequence modifications

A: 21 - 167 (UniProt: P41160)

PDB	External Database	Details
Gly 16	-	expression tag
Gly 17	-	expression tag
Ser 18	-	expression tag
Thr 19	-	expression tag
Gly 20	-	expression tag
Gly 21	Ala 21	conflict

B, F: 22 - 839 (UniProt: P48356)

PDB	External Database	Details
Ala 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
Pro 12	-	expression tag
Gly 13	-	expression tag
Gly 14	-	expression tag
Pro 15	-	expression tag
Gly 16	-	expression tag
Ser 17	-	expression tag
Asp 18	-	expression tag
Glu 19	-	expression tag
Leu 20	-	expression tag
Asp 21	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	204597.4
All*	Total formula weight	204597.4

*Water molecules are not included.