8AVB

Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model).

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
A	0007165	biological_process	signal transduction
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane
F	0004896	molecular_function	cytokine receptor activity
F	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS01353
Number of Residues	57
Details	HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NslgaSlvnfnltfswpmskvsaveslsayplssscvi...LsWtlsPddysll...YlvIeW

Chain	Residue	Details
B	ASN716-TRP772

---

site_id	PS01355
Number of Residues	31
Details	HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. VlpgssyevqVRskrldgsgv...........WSdWSspqvF

Chain	Residue	Details
B	VAL296-PHE326

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	186
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	196
Details	Domain: {"description":"Ig-like"}

Chain

Residue

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site_id	SWS_FT_FI3
Number of Residues	190
Details	Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	184
Details	Domain: {"description":"Fibronectin type-III 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	34
Details	Region: {"description":"Leptin-binding","evidences":[{"source":"UniProtKB","id":"P48357","evidenceCode":"ECO:0000250"}]}

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Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	8
Details	Motif: {"description":"WSXWS motif"}

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Details

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site_id	SWS_FT_FI7
Number of Residues	22
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

Details

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