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PDB: 236 件
4EEY
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BU of 4eey by Molmil
Crystal structure of human DNA polymerase eta in ternary complex with a cisplatin DNA adduct
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*TP*GP*GP*TP*CP*TP*CP*CP*TP*CP*C)-3', 5'-D(*TP*GP*GP*AP*GP*GP*AP*GP*A)-3', ...
著者Ummat, A, Rechkoblit, O, Jain, R, Choudhury, J.R, Johnson, R.E, Silverstein, T.D, Buku, A, Lone, S, Prakash, L, Prakash, S, Aggarwal, A.K.
登録日2012-03-28
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Structural basis for cisplatin DNA damage tolerance by human polymerase {eta} during cancer chemotherapy.
Nat.Struct.Mol.Biol., 19, 2012
6WK6
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BU of 6wk6 by Molmil
Crystal structure of human polymerase eta complexed with Xanthine containing DNA
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(3ZO)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ...
著者Jung, H, Lee, S.
登録日2020-04-15
公開日2021-01-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase.
Biochem.J., 477, 2020
8EVE
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BU of 8eve by Molmil
HUMAN DNA POLYMERASE ETA INSERTION COMPLEX
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Pallan, P.S, Egli, M.
登録日2022-10-20
公開日2023-08-02
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The peroxidation-derived DNA adduct, 6-oxo-M 1 dG, is a strong block to replication by human DNA polymerase eta.
J.Biol.Chem., 299, 2023
6UI2
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BU of 6ui2 by Molmil
Structure of human DNA polymerase eta complexed with N7MG in the template base paired with incoming non-hydrolyzable CTP
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(FMG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Koag, M.C, Lee, S.
登録日2019-09-30
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase eta.
Molecules, 24, 2019
4J9R
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BU of 4j9r by Molmil
Human DNA polymerase eta-DNA translocated binary complex with TG mispair
分子名称: DNA (5'-D(*T*AP*CP*TP*TP*AP*TP*GP*AP*CP*GP*T)-3'), DNA (5'-D(P*TP*AP*CP*GP*TP*CP*AP*TP*G)-3'), DNA polymerase eta, ...
著者Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W.
登録日2013-02-16
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Proc.Natl.Acad.Sci.USA, 110, 2013
5DLG
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BU of 5dlg by Molmil
Crystal Structure of Human DNA Polymerase Eta Inserting dGMPNPP Opposite O4-Methylhymidine
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(5DB)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Patra, A, OFlaherty, D.K, Egli, M.
登録日2015-09-04
公開日2016-08-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.351 Å)
主引用文献Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta.
Chem Sci, 7, 2016
6PZ3
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BU of 6pz3 by Molmil
Polymerase Eta-catalyzed insertion of correct G opposite template cytarabine (AraC) residue
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA Primer strand, DNA polymerase eta, ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2019-07-31
公開日2019-11-20
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.395 Å)
主引用文献Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta.
Sci Rep, 9, 2019
8E8J
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BU of 8e8j by Molmil
Human DNA polymerase eta-DNA-rG-ended primer-dGMPNPP ternary mismatch complex with Mg2+
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*AP*TP*TP*CP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ...
著者Chang, C, Gao, Y.
登録日2022-08-25
公開日2023-02-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity.
J.Biol.Chem., 299, 2023
8E88
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BU of 8e88 by Molmil
Human DNA polymerase eta-DNA-rU-ended primer-dGMPNPP ternary mismatch complex with Mg2+
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ...
著者Chang, C, Gao, Y.
登録日2022-08-25
公開日2023-02-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity.
J.Biol.Chem., 299, 2023
8E8K
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BU of 8e8k by Molmil
Human DNA polymerase eta-DNA-rC-ended primer-dGMPNPP ternary mismatch complex with Mg2+
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ...
著者Chang, C, Gao, Y.
登録日2022-08-25
公開日2023-02-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity.
J.Biol.Chem., 299, 2023
6PLC
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BU of 6plc by Molmil
Structure of human DNA polymerase eta complexed with 8OA in the template base paired with incoming non-hydrolyzable GTP
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(A38)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Koag, M.C, Lee, S.
登録日2019-06-30
公開日2020-04-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine.
Nucleic Acids Res., 48, 2020
4DL6
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BU of 4dl6 by Molmil
Human DNA polymerase eta extending primer immediately after cisplatin crosslink (Pt-GG3).
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, Cisplatin, DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*CP*C)-3'), ...
著者Zhao, Y, Biertumpfel, C, Gregory, M, Hua, Y, Hanaoka, F, Yang, W.
登録日2012-02-05
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
Proc.Natl.Acad.Sci.USA, 109, 2012
6PL7
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BU of 6pl7 by Molmil
Structure of human DNA polymerase eta complexed with A in the template base paired with incoming non-hydrolyzable TTP
分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*AP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Koag, M.C, Lee, S.
登録日2019-06-30
公開日2020-07-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of human DNA polymerase eta complexed with A in the template base paired with incoming non-hydrolyzable TTP
To Be Published
6UQI
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BU of 6uqi by Molmil
Crystal structure of Q38A human DNA polymerase eta bound with 8-oxoadenine (oxoA) and non-hydrolyzable dGTP analog (dGTP*)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(A38)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Jung, H, Lee, S.
登録日2019-10-19
公開日2020-10-28
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of Q38A human DNA polymerase eta bound with 8-oxoadenine (oxoA) and non-hydrolyzable dGTP analog (dGTP*)
To Be Published
3TQ1
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BU of 3tq1 by Molmil
Human DNA Polymerase eta in binary complex with DNA
分子名称: DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*TP*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta
著者Ummat, A, Silverstein, T.D, Jain, R, Buku, A, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K.
登録日2011-09-08
公開日2012-02-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.556 Å)
主引用文献Human DNA Polymerase Eta Is Pre-Aligned for dNTP Binding and Catalysis.
J.Mol.Biol., 415, 2012
8GML
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BU of 8gml by Molmil
Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across dG
分子名称: 2'-deoxy-5-fluorouridine 5'-(tetrahydrogen triphosphate), CALCIUM ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), ...
著者Jung, H.
登録日2023-03-26
公開日2023-09-20
実験手法X-RAY DIFFRACTION (2.567 Å)
主引用文献Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across dA
To Be Published
6W5X
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BU of 6w5x by Molmil
Crystal structure of human polymerase eta complexed with N7-benzylguanine and dCTP*
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(DRG)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ...
著者Jung, H, Lee, S.
登録日2020-03-14
公開日2021-03-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Crystal structure of human polymerase eta complexed with N7-benzylguanine and dCTP*
To Be Published
5F9L
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BU of 5f9l by Molmil
CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING dAMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N2-ETHENODEOXYGUANOSINE LESION
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(GNE)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Patra, A, Egli, M.
登録日2015-12-09
公開日2016-12-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.592 Å)
主引用文献Bypass of the 1, N2-Ethenodeoxyguanosine Lesion by Human DNA Polymerase Eta
To Be Published
4J9O
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BU of 4j9o by Molmil
Human DNA polymerase eta-DNA ternary complex: primer extension after a T:G mispair
分子名称: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*T*AP*CP*GP*TP*CP*AP*TP*G)-3'), ...
著者Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W.
登録日2013-02-16
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.597 Å)
主引用文献Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Proc.Natl.Acad.Sci.USA, 110, 2013
5JUM
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BU of 5jum by Molmil
Crystal Structure of Human DNA Polymerase Eta Inserting dCTP Opposite N-(2'-deoxyguanosin-8- yl)-3-aminobenzanthrone (C8-dG-ABA)
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Patra, A, Politica, D.A, Stone, M.P, Egli, M.
登録日2016-05-10
公開日2016-09-07
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Mechanism of Error-Free Bypass of the Environmental Carcinogen N-(2'-Deoxyguanosin-8-yl)-3-aminobenzanthrone Adduct by Human DNA Polymerase eta.
Chembiochem, 17, 2016
4RU9
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BU of 4ru9 by Molmil
Crystal structure of human DNA polymerase eta inserting dCMPNPP opposite a MeFapy-dG adducted DNA template
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA polymerase eta, MAGNESIUM ION, ...
著者Patra, A, Egli, M.
登録日2014-11-18
公開日2015-08-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV.
J.Am.Chem.Soc., 137, 2015
6V5K
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BU of 6v5k by Molmil
Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP*
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*T*(QRV)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ...
著者Jung, H, Lee, S.
登録日2019-12-04
公開日2020-12-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP*
To Be Published
5L1I
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BU of 5l1i by Molmil
Crystal Structure of Human DNA Polymerase Eta Inserting dCTP Opposite O6-Methyl-2'-deoxyguanosine
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*C)-3'), ...
著者Patra, A, Egli, M.
登録日2016-07-29
公開日2016-10-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
8GKR
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BU of 8gkr by Molmil
Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across dA
分子名称: 2'-deoxy-5-fluorouridine 5'-(tetrahydrogen triphosphate), CALCIUM ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), ...
著者Jung, H.
登録日2023-03-20
公開日2023-09-20
実験手法X-RAY DIFFRACTION (2.784 Å)
主引用文献Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across dA
To Be Published
4Q8F
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BU of 4q8f by Molmil
Human DNA polymerase eta extending primer immediately after a phenanthriplatin adducted G
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, 5'-D(*AP*GP*TP*GP*TP*GP*AP*C)-3', 5'-D(*CP*AP*TP*CP*GP*TP*CP*AP*CP*AP*CP*T)-3', ...
著者Gregory, M.T, Yang, W.
登録日2014-04-26
公開日2014-07-02
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.797 Å)
主引用文献Structural and mechanistic studies of polymerase eta bypass of phenanthriplatin DNA damage.
Proc.Natl.Acad.Sci.USA, 111, 2014

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件を2024-08-07に公開中

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