6PZ3
Polymerase Eta-catalyzed insertion of correct G opposite template cytarabine (AraC) residue
Summary for 6PZ3
| Entry DOI | 10.2210/pdb6pz3/pdb |
| Descriptor | DNA polymerase eta, DNA Primer strand, DNA template containing cytarabine (AraC) residue, ... (7 entities in total) |
| Functional Keywords | cytarabin, lesion bypass, dna damage, replication, chemotherapy, transferase |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 55357.66 |
| Authors | Rechkoblit, O.,Aggarwal, A.K. (deposition date: 2019-07-31, release date: 2019-11-20, Last modification date: 2024-03-13) |
| Primary citation | Rechkoblit, O.,Johnson, R.E.,Buku, A.,Prakash, L.,Prakash, S.,Aggarwal, A.K. Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta. Sci Rep, 9:16400-16400, 2019 Cited by PubMed: 31704958DOI: 10.1038/s41598-019-52703-7 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.395 Å) |
Structure validation
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